This is the Introduction to a special issue examining the West African Ebola epidemic of 2014-2016; there is no abstract. **NOTE: This is a preprint version** of Bolten, Catherine, and Susan Shepler. 'Producing Ebola: Creating Knowledge In and About an Epidemic.' *Anthropological Quarterly* 90, no. 2 (2017): 349-368. https://doi.org/10.1353/anq.2017.0022.