Exosomal biomarkers diagnostic of tuberculosis
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posted on 2022-01-16, 00:00 authored by Jeffrey S. Schorey, Prachi Pratap Singh, Yong ChengThe disclosure provides a method for diagnosing an active mycobacterium tuberculosis infection by detecting certain RNA biomarkers present in secreted extracellular vesicles isolated from a bodily fluid. The RNA biomarkers in the secreted extracellular vesicles may include a certain mycobacterium RNAs as well as certain host cell RNAs. Also provided is an RNA signature of certain mycobacterium and host cell RNA present in secreted extracellular vesicles indicative of an active tuberculosis infection.
History
Patent Number
US 10526665 B2Other Application
15/449,324Inventor
Jeffrey S. Schorey Prachi Pratap Singh Yong ChengInventor from Local Institution
Jeffrey S. Schorey Prachi Pratap Singh Yong ChengAssignee
University of Notre Dame du LacDate Modified
2022-02-04Language
- English
Claims
20Prior Publication Number
US 2017/0253916 A1Cooperative Patent Classification Codes
C12Q 1/6883 (20130101); C12Q 1/689 (20130101); C12Q 2600/158 (20130101)Contributor
Jeffrey S. Schorey|Prachi Pratap Singh|Yong ChengInternational Patent Classification Codes
C12Q 1/68 (20180101); C12Q 1/689 (20180101)Usage metrics
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