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Exosomes and diagnostic biomarkers

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posted on 2017-08-01, 00:00 authored by Jeffrey S. Schorey, Karen M. Dobos

The invention provides methods for the detection of M. tuberculosis proteins in or on exosomes derived from infected individuals. The methods can use a proteomic approach including mass spectroscopy, data mining and multiplex reaction monitoring to quickly examine a large amount of M. tuberculosis proteins to determine the best biomarkers for use in diagnostic tests to identify active TB patients.

History

Patent Number

US 9255924 B2

Other Application

14/052,378

USPTO Link

http://patft1.uspto.gov/netacgi/nph-Parser?patentnumber=9255924

Inventor

Jeffrey S. Schorey Karen M. Dobos

Inventor from Local Institution

Jeffrey S. Schorey

Assignee

University of Notre Dame du Lac Colorado State University Research Foundation (Fort Collins, CO)

Date Modified

2017-08-01

Language

English

Claims

11

Prior Publication Number

US 20140113305 A1

Publisher

U.S. Patent and Trademark Office

Contributor

Jeffrey S. Schorey

International Patent Classification Codes

A61K 39/04 (20060101); G01N 33/569 (20060101); G01N 33/68 (20060101); C12N 1/20 (20060101); C07K 14/35 (20060101)

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