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Method and apparatus for AC electrospray

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posted on 2016-06-07, 00:00 authored by Dmitri Lastochkin, Hsueh-Chia ChangHsueh-Chia Chang, Leslie Yeo, Shau-Chun Paul Wang, Zachary Gagnon
The present invention provides an electrospray device using a high frequency alternating current (AC) above 10 kHz to generate fine micron sized drops. The apparatus generally functions by applying a high frequency alternating current electric field across one or more micro-needles and one or more conducting elements. The present invention may be used to generate aerosol drops for respiratory drug delivery or as a microencapsulation technique for the encapsulation of drugs, DNA, protein, osteogenic or dermatological growth factors, bacteria, viruses, immobilized enzyme receptors and fluorescent particles for controlled release drug delivery, tissue or bone engineering, clinical or environmental field testing and as biosensors for clinical or drug monitoring. In addition, the present invention may be used to synthesize biodegradable fibers as bioscaffolds for tissue engineering, surgical sutures or medical gauze that enhance blood coagulation, and further may be encapsulated by other agents.

History

Patent Number

US 8267914 B1

Other Application

10/965,834

Inventor

Hsueh-Chia Chang Shau-Chun Paul Wang Dmitri Lastochkin Leslie Yeo Zachary Gagnon

Inventor from Local Institution

Hsueh-Chia Chang Shau-Chun Paul Wang Dmitri Lastochkin Leslie Yeo Zachary Gagnon

Assignee

University of Notre Dame Du Lac

Date Modified

2017-08-02

Language

  • English

Claims

41

Publisher

United States Patent and Trademark Office

Cooperative Patent Classification Codes

A61M 11/00 (20130101); A61M 15/02 (20130101); A61K 9/0073 (20130101); A61M 2037/0061 (20130101)

Contributor

Hsueh-Chia Chang|Shau-Chun Paul Wang|Dmitri Lastochkin|Leslie Yeo|Zachary Gagnon

International Patent Classification Codes

A61M 31/00 (20060101)

US Patent Classification Codes

604/500; 128/200.14; 604/173; 604/20

Additional Groups

  • Aerospace and Mechanical Engineering
  • Chemical and Biomolecular Engineering

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