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Method for preparing largazole analogs and uses thereof

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posted on 2022-01-16, 00:00 authored by Albert A. Bowers, Dane Clausen, James E. Bradner, Jennifer Marie Guerra, Olaf G. Wiest, Robert M. Williams, Tenaya L. Newkirk

Analogs of largazole are described herein. Methods of treating cancer and blood disorders using largazole and largazole analogs and pharmaceutical compositions comprising the same are additionally described herein. Methods for preparing largazole analogs are likewise described.

History

Patent Number

US 10676504 B2

Other Application

15/555,755

USPTO Link

http://patft1.uspto.gov/netacgi/nph-Parser?patentnumber=10676504

Inventor

Robert M. Williams James E. Bradner Dane Clausen Olaf G. Wiest Tenaya L. Newkirk Albert A. Bowers Jennifer Marie Guerra

Inventor from Local Institution

Olaf G. Wiest

Assignee

Colorado State University Research Foundation (Fort Collins, CO) Dana-Farber Cancer Institute, Inc. (Boston, MA) University of Notre Dame du Lac

Date Modified

2022-02-04

Language

English

Claims

12

Prior Publication Number

US 20180044376 A1

Cooperative Patent Classification Codes

C07D 513/18 (20130101); A61K 45/06 (20130101); C07B 59/008 (20130101); A61K 31/437 (20130101); C07K 5/06052 (20130101); A61K 38/05 (20130101); A61K 31/429 (20130101); A61K 31/437 (20130101); A61K 2300/00 (20130101); A61K 31/429 (20130101); A61K 2300/00 (20130101); C07B 2200/05 (20130101)

Contributor

Olaf G. Wiest

International Patent Classification Codes

A61K 38/00 (20060101); C07K 5/062 (20060101); C07D 513/18 (20060101); A61K 31/437 (20060101); C07B 59/00 (20060101); A61K 38/05 (20060101); A61K 45/06 (20060101); A61K 31/429 (20060101)

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Licence

CC BY-NC-SA 3.0

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