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Method for preparing largazole analogs and uses thereof

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posted on 2016-06-07, 00:00 authored by Albert A. Bowers, James E. Bradner, Olaf G. Wiest, Robert M. Williams, Tenaya L. Newkirk
Analogs of largazole are described herein. Methods of treating cancer and blood disorders using largazole and largazole analogs and pharmaceutical compositions comprising the same are additionally described herein. Methods for preparing largazole analogs are likewise described.

History

Patent Number

US 8513290 B2

Other Application

13/490,693

Inventor

Robert M. Williams James E. Bradner Albert A. Bowers Tenaya L. Newkirk Olaf G. Wiest

Inventor from Local Institution

Olaf Wiest

Assignee

University of Notre Dame Du Lac Colorado State University Research Foundation (Fort Collins, CO) Dana-Farber Cancer Institute, Inc. (Boston, MA)

Date Modified

2022-01-16

Language

  • English

Claims

9

Prior Publication Number

US 20120264794 A1

Publisher

United States Patent and Trademark Office

Cooperative Patent Classification Codes

C07D 498/18 (20130101); A61K 39/39558 (20130101); A61K 31/429 (20130101); C07D 513/18 (20130101)

Contributor

Olaf Wiest

International Patent Classification Codes

A61K 31/429 (20060101); A61K 31/424 (20060101); C07D 513/22 (20060101); C07D 513/18 (20060101); C07D 498/18 (20060101)

US Patent Classification Codes

514/366; 514/374; 514/375; 514/471; 548/122; 548/125; 548/126; 548/215; 548/217; 548/220;

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