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Process for preparing .beta.-hydroxy-.alpha. amino acids

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posted on 2016-06-07, 00:00 authored by Marvin J MillerMarvin J Miller
.beta.-Hydroxy-.alpha.-amino acids are obtained via serine hydroxymethyltransferase catalyzed condensation of aldehydes with glycine. The predominant product with most aldehydes is the L-erythro diastereomer. For example, succinic semialdehyde methylester is condensed with glycine in the process to provide L-erythro .alpha.-amino hydroxy adipic acid mono methyl ester.

History

Patent Number

US 5266468 B2

Other Application

07/918,878

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Inventor

Marvin J. Miller

Inventor from Local Institution

Marvin J. Miller

Assignee

University of Notre Dame Du Lac

Date Modified

2016-06-07

Language

  • English

Claims

3

Publisher

United States Patent and Trademark Office

Cooperative Patent Classification Codes

C12N 9/1014 (20130101); C12P 13/08 (20130101); C12P 13/04 (20130101)

Contributor

Marvin J. Miller

International Patent Classification Codes

C12P 13/00 (20060101); C12P 13/08 (20060101); C12P 13/04 (20060101); C12N 9/10 (20060101); C12P 013/04 (); C07C 215/00 ()

US Patent Classification Codes

435/106; 564/503;

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    CC BY 4.0

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