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Synthesis and utility of new capgroup largazole analogs

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posted on 2022-01-16, 00:00 authored by Christine Elizabeth Dunne, Dane Clausen, James E. Bradner, Le Zhao, Olaf G. Wiest, Robert M. Williams

Analogs of largazole are described herein. Methods of treating cancer, blood disorders, autoimmune disease, and Alzheimer's Disease using largazole analogs and pharmaceutical compositions comprising the same are additionally described herein. Methods for preparing largazole analogs are likewise described.

History

Patent Number

US 10538534 B2

Other Application

15/555,792

USPTO Link

http://patft1.uspto.gov/netacgi/nph-Parser?patentnumber=10538534

Inventor

Robert M. Williams James E. Bradner Dane Clausen Olaf G. Wiest Le Zhao Christine Elizabeth Dunne

Inventor from Local Institution

Olaf G. Wiest

Assignee

Colorado State University Research Foundation (Fort Collins, CO) Dana-Farber Cancer Institute, Inc. (Boston, MA) University of Notre Dame du Lac

Date Modified

2022-02-04

Language

English

Claims

18

Prior Publication Number

US 2018/0057510 A1

Cooperative Patent Classification Codes

A61P 37/02 (20180101); A61P 35/00 (20180101); A61P 7/00 (20180101); A61K 45/06 (20130101); A61P 7/06 (20180101); C07D 513/18 (20130101); A61K 31/429 (20130101); A61P 25/28 (20180101); A61P 35/02 (20180101); A61P 43/00 (20180101)

Contributor

Olaf G. Wiest

International Patent Classification Codes

C07D 513/18 (20060101); A61K 31/429 (20060101); A61K 45/06 (20060101)

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CC BY-NC-SA 3.0

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