Conformationally Constrained Aminoglycosides: Ribosomal Binding Probes and Potential Antibiotics

Conformational constraints were placed on derivatives of neamine, a subclass of aminoglycosides, via an N3-N6' linkage in order to investigate the relevance of conformational states in binding the bacterial ribosome. Additionally, an understanding of how this new class of compounds behaves in the presence of aminoglycoside modifying enzymes was sought.