Metal-Mediated Ring Opening Reactions of Acylnitroso Cycloadducts: Inter- and Intramolecular Enolate Additions and Application to Carbocyclic Nucleoside Synthesis

Methodology was developed on a library of cycloadducts derived from a Diels-Alder reaction involving acyl nitroso species using enolate species under varying conditions. Also, a palladium catalyzed decarboxylation reaction was developed as a key step in a new process to synthesize homoaristeromycin, a carbocylic nucleoside possessing anti-viral activity.