University of Notre Dame
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Glen Niebur

Publications

  • Bone marrow mechanotransduction in porcine explants alters kinase activation and enhances trabecular bone formation in the absence of osteocyte signaling
  • Fluid shear stress in trabecular bone marrow due to low-magnitude high-frequency vibration
  • Indentation experiments and simulation of ovine bone using a viscoelastic-plastic damage model
  • Development of an in vivo rabbit ulnar loading model
  • The CXCL5/CXCR2 axis is sufficient to promote breast cancer colonization during bone metastasis.
  • Effect of defects on the constant-amplitude fatigue behavior of as-built Ti-6Al-4V alloy produced by laser powder bed fusion process: Assessing performance with metallographic analysis and micromechanical simulations
  • Preface: Mechanobiology, why not?
  • Mechanobiology: From Molecular Sensing to Disease
  • Computational Modelling of the Mechanics of Trabecular Bone and Marrow Using Fluid Structure Interaction Techniques
  • Biomedical Modeling: The Role of Transport and Mechanics
  • In vivo microdamage is an indicator of susceptibility to initiation and propagation of microdamage in human femoral trabecular bone
  • A probabilistic damage model based on direct 3-D correlation of strain to damage formation following fatigue loading of rat femora
  • Multiscale Modeling of Trabecular Bone Marrow: Understanding the Micromechanical Environment of Mesenchymal Stem Cells During Osteoporosis
  • The In Situ Mechanics of Trabecular Bone Marrow: The Potential for Mechanobiological Response
  • Alterations in trabecular bone microarchitecture in the ovine spine and distal femur following ovariectomy
  • Characterization of cancellous and cortical bone strain in the in vivo mouse tibial loading model using microCT-based finite element analysis
  • How Bone Tissue and Cells Experience Elevated Temperatures During Orthopaedic Cutting: An Experimental and Computational Investigation
  • Rheological behavior of fresh bone marrow and the effects of storage
  • Hydroxyapatite reinforced collagen scaffolds with improved architecture and mechanical properties
  • Mechanical Stimulation of Bone Marrow In Situ Induces Bone Formation in Trabecular Explants
  • Primary Cilia Exist in a Small Fraction of Cells in Trabecular Bone and Marrow
  • Pressure and shear stress in trabecular bone marrow during whole bone loading.
  • A Novel Bone Bioreactor Used to Model Bone Metastasis Ex Vivo
  • Controlled mechanical loading affects the osteocyte transcriptome in porcine trabecular bone in situ
  • Potassium channel activity controls breast cancer metastasis by affecting β-catenin signaling
  • Mineral deposition and vascular invasion of hydroxyapatite reinforced collagen scaffolds seeded with human adipose-derived stem cells
  • Chapter 5 Future Prospects and Challenges
  • Mechanically induced bone formation is not sensitive to local osteocyte density in rat vertebral cancellous bone
  • Abstract 56: CXCL5 is a master regulator of the dormancy switch to activate metastatic colonization of dormant breast cancer cells during bone metastasis
  • Bone: A Fertile Soil for Cancer Metastasis.
  • Intraoperative biomechanics of lumbar pedicle screw loosening following successful arthrodesis
  • Integration of mechanics and biology in computer simulation of bone remodeling
  • Altered architecture and cell populations affect bone marrow mechanobiology in the osteoporotic human femur
  • Anisotropic Permeability of Trabecular Bone and its Relationship to Fabric and Architecture: A Computational Study
  • Shear Stress in Bone Marrow has a Dose Dependent Effect on cFos Gene Expression in In Situ Culture
  • Effects of mechanobiological signaling in bone marrow on skeletal health
  • Mechanical stimuli and matrix properties modulate cancer spheroid growth in three-dimensional gelatin culture
  • The Effect of Marrow Secretome and Culture Environment on the Rate of Metastatic Breast Cancer Cell Migration in Two and Three Dimensions.
  • The roles of architecture and estrogen depletion in microdamage risk in trabecular bone
  • Erratum to: Anisotropic Permeability of Trabecular Bone and its Relationship to Fabric and Architecture: A Computational Study (Annals of Biomedical Engineering, (2017), 45, 6, (1543-1554), 10.1007/s10439-017-1805-9)
  • Three-dimensional printing of X-ray computed tomography datasets with multiple materials using open-source data processing
  • The sensitivity of nonlinear computational models of trabecular bone to tissue level constitutive model
  • Primary cilia expression in bone marrow in response to mechanical stimulation in explant bioreactor culture
  • Pressure gradients in the trabecular pore space of femurs during physiologic loading
  • Understanding the effects of thermal elevations associated with orthopedic intervention: An experimental and computational investigation
  • Primary cilia knockdown reduces the number of stromal cells in three dimensional ex vivo culture
  • An Experimental and Computational Investigation of Bone Formation in Mechanically Loaded Trabecular Bone Explants
  • Comparison of solid and fluid constitutive models of bone marrow during trabecular bone compression
  • On the influence of marrow on the mechanical behavior of porcine trabecular bone under dynamic loading: A numerical investigation
  • Mineral deposition and vascular invasion of hydroxyapatite reinforced collagen scaffolds seeded with human adipose-derived stem cells
  • Compressive properties of trabecular bone in the distal femur
  • THE EFFECTS OF MICROARCHITECTURE VS. DAMAGE ON THE TOUGHNESS OF TRABECULAR BONE
  • Shear strength and toughness of trabecular bone are more sensitive to density than damage
  • Density and architecture have greater effects on the toughness of trabecular bone than damage
  • Effects of trabecular type and orientation on microdamage susceptibility in trabecular bone
  • The relative influence of apatite crystal orientations and intracortical porosity on the elastic anisotropy of human cortical bone
  • Microdamage propagation in trabecular bone due to changes in loading mode
  • Effect of the Vitamin D Receptor on Bone Geometry and Strength During Gestation and Lactation in Mice
  • High Strain Rate Testing of Bovine Trabecular Bone
  • Improved accuracy of cortical bone mineralization measured by polychromatic microcomputed tomography using a novel high mineral density composite calibration phantom
  • Computational Modeling of Trabecular Bone Mechanics
  • Direct comparison of nanoindentation and macroscopic measurements of bone viscoelasticity
  • Viscoelastic properties of human cortical bone tissue depend on gender and elastic modulus
  • Type and orientation of yielded trabeculae during overloading of trabecular bone along orthogonal directions.
  • Synthesis of a barium sulfate nanoparticle contrast agent for micro-computed tomography of bone microstructure
  • Response to Letter to the Editor from David P. Fyhrie
  • The effect of holding time on nanoindentation measurements of creep in bone
  • Axial-shear interaction effects on microdamage in bovine tibial trabecular bone
  • Contrast-enhanced micro-computed tomography of fatigue microdamage accumulation in human cortical bone
  • Effects of Loading Orientation on the Morphology of the Predicted Yielded Regions in Trabecular Bone
  • Mechanical property determination of bone through nano- and micro-indentation testing and finite element simulation
  • A fully anisotropic hierarchical hybrid cellular automaton algorithm to simulate bone remodeling
  • Bone ingrowth into a porous coated implant predicted by a mechano-regulatory tissue differentiation algorithm
  • Detection of trabecular bone microdamage by micro-computed tomography
  • Compressive properties of trabecular bone in the distal femur
  • Detection of fatigue microdamage in whole rat femora using contrast-enhanced micro-computed tomography.
  • A semi-automated method for hexahedral mesh construction of human vertebrae from CT scans
  • Micro-computed tomography of fatigue microdamage in cortical bone using a barium sulfate contrast agent
  • Shear strength and toughness of trabecular bone are more sensitive to density than damage
  • OSTEOGENIC DIFFERENTIATION OF MESENCHYMAL STEM CELLS IS REGULATED BY OSTEOCYTE AND OSTEOBLAST CELLS IN A SIMPLIFIED BONE NICHE
  • Computational modeling of trabecular bone mechanics
  • Semi-automated hexahedral mesh generation of human vertebrae by isoparametric mapping
  • Mechanical validation of computed tomographic quantification of posterolateral intertransverse lumbar fusion
  • Effects of external loading on the morphology of the yielded regions in trabecular bone predicted by FEA
  • A Fully Anisotropic Hierarchical Hybrid Cellular Automata Methodology to Simulate Bone Remodeling
  • Computational modeling of the healing process in tendon
  • A mathematical model of cell mediated tissue adaptation to mechanical loading
  • Bony ingrowth into a porous coated implant predicted by a mechano-regulatory tissue differentiation algorithm
  • Sensitivity of b-spline surface fitting of a verterbral endplate using least squares
  • Finite element analysis of porous coating design for soft tissue attachment
  • Synthesis of a barium sulfate nanoparticle contrast agent for micro-computed tomography of bone microstructure
  • Osteogenic differentiation of mesenchymal stem cells is regulated by osteocyte and osteoblast cells in a simplified bone niche
  • Investigation of osteoclast resorption mechanisms in a hybrid cellular automaton model of bone remodeling
  • Shear stress within trabecular bone marrow due to low magnitude high frequency vibration
  • Fatigue microdamage in bovine cortical bone imaged by micro-computed tomography using a barium sulfate contrast agent
  • High fidelity computational model of bone remodeling cellular mechanisms
  • Signaling pathways for bone resorption predicted as a hybrid cellular automaton process
  • Axial-shear interaction effects on microdamage in bovine tibial trabecular bone
  • Response to Letter to the Editor from David P. Fyhrie
  • Prediction of mechanical properties of vertebral trabecular bone using microstructural finite element models
  • Biaxial Failure Behavior of Bovine Tibial Trabecular Bone
  • Ligament length during circumduction of the trapeziometacarpal joint
  • Preparation of On-Axis Cylindrical Trabecular Bone Specimens Using Micro-CT Imaging
  • A Grammar Driven Data Translation System for Computer Integrated Manufacturing
  • Roles of deltoid and rotator cuff muscles in shoulder elevation
  • Comparison of the elastic and yield properties of human femoral trabecular and cortical bone tissue
  • A Grammar Driven Data Translation System for Computer Integrated Manufacturing
  • Biaxial Failure Behavior of Bovine Tibial Trabecular Bone
  • Feasibility of using a magnetic tracking device for measuring carpal kinematics
  • KINEMATICS OF THE TRAPEZIOMETACARPAL JOINT AFTER SECTIONING OF LIGAMENTS
  • Determination of the proximity tolerance for measurement of surface contact areas using a magnetic tracking device
  • The relevance of the moment arm of shoulder muscles with respect to axial rotation of the glenohumeral joint in four positions
  • Biomechanical analysis of the trapeziometacarpal joint after surface replacement arthroplasty
  • Biomechanical effects of intraspecimen variations in tissue modulus for trabecular bone
  • Convergence behavior of high-resolution finite element models of trabecular bone
  • Effects of damage on the orthotropic material symmetry of bovine tibial trabecular bone
  • Kinematics of the trapeziometacarpal joint: A biomechanical analysis comparing tendon interposition arthroplasty and total-joint arthroplasty
  • MALROTATION OF THE HUMERAL COMPONENT OF THE CAPITELLOCONDYLAR TOTAL ELBOW REPLACEMENT IS NOT THE SOLE CAUSE OF DISLOCATION
  • MOTION AND LAXITY OF THE CAPITELLOCONDYLAR TOTAL ELBOW PROSTHESIS
  • The effects of wrist distraction on carpal kinematics
  • KINEMATICS AND STABILITY OF THE NORWAY ELBOW - A CADAVERIC STUDY
  • KINEMATICS OF THE NORMAL TRAPEZIOMETACARPAL JOINT
  • Kinematics of the proximal interphalangeal joint of the finger after surface replacement
  • Comparison of two methods for computing abduction moment arms of the rotator cuff
  • UNTITLED - REPLY
  • Forming and bending of metal foams
  • High-resolution finite element models with tissue strength asymmetry accurately predict failure of trabecular bone
  • Sensitivity of damage predictions to tissue level yield properties and apparent loading conditions
  • Mechanical advantage of the thumb muscles
  • Three-dimensional imaging of microdamage in bone using micro-ct
  • Forming of metal foams
  • Biaxial yield strains in bovine tibial trabecular bone do not depend on volume fraction
  • Elastic and failure properties of trabecular tissue at the human femoral neck
  • Damage behavior of trabecular bone
  • Investigation of trabecular bone failure using high-resolution finite element models
  • Simulation of trabecular bone yield using nonlinear finite element analysis
  • Convergence characteristics of voxel based finite element models of trabecular bone
  • The use of a direct current electromagnetic tracking device in a metallic environment
  • Articular contact area in an unconstrained metacarpophalangeal prosthesis
  • SIMULATION OF TRABECULAR BONE YIELD USING NONLINEAR FINITE ELEMENT ANALYSIS
  • A grammar driven data translation system for computer integrated manufacturing
  • Bone structure adaptation as a cellular automaton optimization process
  • Biomechanical analysis of the trapeziometacarpal joint after surface replacement arthroplasty
  • CONVERGENCE CHARACTERISTICS OF VOXEL BASED FINITE ELEMENT MODELS OF TRABECULAR BONE
  • Ligament length during circumduction of the trapeziometacarpal joint
  • Motion and laxity of the capitellocondylar total elbow prosthesis
  • Comparison of two methods for computing abduction moment arms of the rotator cuff
  • Damage behavior of trabecular bone
  • Mechanical advantage of the thumb muscles
  • Ligament length during circumduction of the trapeziometacarpal joint after ligament sectioning
  • Biomechanics of Trabecular Bone
  • Preparation of On-Axis Cylindrical Trabecular Bone Specimens Using Micro-CT Imaging
  • Topology Optimization Using a Hybrid Cellular Automaton Method With Local Control Rules

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Co-workers & collaborators

  • Kimberly J. Curtis

  • Kimberly Curtis

  • Mary Varsanik

  • Thomas Coughlin

  • Meghana Machireddy

  • Sarah Nano

Glen Niebur's public data