Centers and Institutes
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List of files deposited in CurateND that match your search criteria
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1
Doctoral Dissertation
- Author:
- Jeremy Steeger
- Advisory Committee:
- Don A. Howard, Miklós Rédei, Patricia Blanchette, Nicholas Y. Teh, Curtis Franks
- Degree Area:
- History and Philosophy of Science
- Degree:
- Doctor of Philosophy
- Defense Date:
- 2019-06-25
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2
Doctoral Dissertation
- Author:
- Angela J. Lederach
- Advisory Committee:
- Catherine E. Bolten
- Degree Area:
- Anthropology, Peace Studies
- Degree:
- Doctor of Philosophy
- Defense Date:
- 2019-04-26
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3
Doctoral Dissertation
- Author:
- Erik Z. D. Ellis
- Advisory Committee:
- Aldo Tagliabue, Alexander Beihammer, Hildegund Müller, Peter Jeffery
- Degree Area:
- Medieval Studies
- Degree:
- Doctor of Philosophy
- Defense Date:
- 2019-03-27
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4
Doctoral Dissertation
- Author:
- Charles C. Yost
- Advisory Committee:
- Alexis Torrance, Alex Beihammer, John Monfasani, Yury Avvakumov
- Degree Area:
- Medieval Studies
- Degree:
- Doctor of Philosophy
- Defense Date:
- 2019-03-29
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5
Doctoral Dissertation
- Author:
- Caitlin Stevenson
- Advisory Committee:
- John Van Engen
- Degree Area:
- Medieval Studies
- Degree:
- Doctor of Philosophy
- Defense Date:
- 2019-03-05
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6
Doctoral Dissertation
- Author:
- Emily Maiden
- Advisory Committee:
- Jaimie Bleck, George Lopez, Susan St. Ville
- Degree Area:
- Peace Studies
- Degree:
- Doctor of Philosophy
- Defense Date:
- 2019-03-01
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- Author(s):
- Matthew Sisk
- Abstract:
Lead exposure is a major health hazard affecting children and their growth and is a concern in many urban areas around the world. One such city in the United States (US), South Bend Indiana, gained attention for its high levels of lead in blood and relatively low testing rates for children. We assessed current lead screening practices in South Bend and the surrounding St. Joseph County (SJC). The 2005–2015 lead screening data included 18,526 unique children. Lead screening rates ranged from 4…
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- Author(s):
- Yide Zhang
- Abstract:
In cancer and all biomedical researches, we always need a microscope with better imaging precision, speed, functionality, and depth, so that the diagnostics and treatments of cancer and other diseases can be accurate, fast, and noninvasive. However, conventional fluorescence microscopes cannot satisfy these needs due to physical limits on resolution, speed, information, and depth. In this work, we aim to overcome these limits using novel super-resolution microscopy and high-speed quantitative…
- Date Created:
- 2018-04-09
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- Author(s):
- Yide Zhang, Scott S. Howard, Cody J. Smith
- Abstract:
Super-resolution microscopy is broadening our in-depth understanding of cellular structure. However, super-resolution approaches are limited, for numerous reasons, from utilization in longer-term intravital imaging. We devised a combinatorial imaging technique that combines deconvolution with stepwise optical saturation microscopy (DeSOS) to circumvent this issue and image cells in their native physiological environment. Other than a traditional confocal or two-photon microscope, this approac…
- Date Created:
- 2019-01-09
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- Author(s):
- Md Suhail Alam, Bruce Cooper, Kasturi Halder
- Abstract:
Histone deacetylase (HDAC) inhibitors are of significant interest as drugs. However, their use in neurological disorders has raised concern because HDACs are required for brain function. We have previously shown that a triple combination formulation (TCF) of the pan HDACi vorinostat (Vo) improves pharmacokinetic exposure and entry of Vo into the brain. TCF treatment significantly delayed both neurodegeneration and death in the Npc1nmf164 murine model of Niemann Pick Type C (NPC) disease. The …
- Date Published:
- 2017-09
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- Author(s):
- Manuela Lahne, Clare E. Yarka, Michael E. Petravick, Jingling Li, David R. Hyde
- Abstract:
Sox2 is a well-established neuronal stem cell-associated transcription factor that regulates neural development and adult neurogenesis in vertebrates, and is one of the critical genes used to reprogram differentiated cells into induced pluripotent stem cells. We examined if Sox2 was involved in the early reprogramming-like events that Müller glia undergo as they upregulate many pluripotency- and neural stem cell-associated genes required for proliferation in light-damaged adult zebrafish reti…
- Date Published:
- 2017-08
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12
Article
- Author(s):
- Jeff Schorey, Yong Cheng
- Abstract:
Extracellular vesicles (EVs) have been shown to carry microbial components and function in the host defense against infections. In this study, we demonstrate that Mycobacterium tuberculosis (M.tb) RNA is delivered into macrophage-derived EVs through an M.tb SecA2-dependent pathway, and that EVs released from M.tb-infected macrophages stimulate a host RIG-I/MAVS/TBK1/IRF3 RNA sensing pathway, leading to type I interferon production in recipient cells. These EVs also promote, in a RIG-I/MAVS-de…
- Date Published:
- 2018-06