Center for Rare and Neglected Diseases

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• 1

  Article

  Tolerance of chronic HDACi-administration used for treatment of neurological and visceral disease including lung pathogenesis.
  

  Author(s):

  Md Suhail Alam, Bruce Cooper, Kasturi Halder

  Abstract:

  Histone deacetylase (HDAC) inhibitors are of significant interest as drugs. However, their use in neurological disorders has raised concern because HDACs are required for brain function. We have previously shown that a triple combination formulation (TCF) of the pan HDACi vorinostat (Vo) improves pharmacokinetic exposure and entry of Vo into the brain. TCF treatment significantly delayed both neurodegeneration and death in the Npc1nmf164 murine model of Niemann Pick Type C (NPC) disease. The …

  Date Published:

  2017-09

  Record Visibility:

  Public

• 2

  Article

  Extracellular Vesicles promote host immunity during an M. tuberculosis infection through RNA Sensing
  

  Author(s):

  Jeff Schorey, Yong Cheng

  Abstract:

  Extracellular vesicles (EVs) have been shown to carry microbial components and function in the host defense against infections. In this study, we demonstrate that Mycobacterium tuberculosis (M.tb) RNA is delivered into macrophage-derived EVs through an M.tb SecA2-dependent pathway, and that EVs released from M.tb-infected macrophages stimulate a host RIG-I/MAVS/TBK1/IRF3 RNA sensing pathway, leading to type I interferon production in recipient cells. These EVs also promote, in a RIG-I/MAVS-de…

  Date Published:

  2018-06

  Record Visibility:

  Public