Center for Stem Cells and Regenerative Medicine

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  Article

  Sox2 regulates Müller glia reprogramming and proliferation in the regenerating zebrafish retina via Lin28 and Ascl1a
  

  Author(s):

  Manuela Lahne, Clare E. Yarka, Michael E. Petravick, Jingling Li, David R. Hyde

  Abstract:

  Sox2 is a well-established neuronal stem cell-associated transcription factor that regulates neural development and adult neurogenesis in vertebrates, and is one of the critical genes used to reprogram differentiated cells into induced pluripotent stem cells. We examined if Sox2 was involved in the early reprogramming-like events that Müller glia undergo as they upregulate many pluripotency- and neural stem cell-associated genes required for proliferation in light-damaged adult zebrafish reti…

  Date Published:

  2017-08

  Record Visibility:

  Public