Center for Stem Cells and Regenerative Medicine

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  • Author(s):
    Manuela Lahne, Clare E. Yarka, Michael E. Petravick, Jingling Li, David R. Hyde
    Abstract:

    Sox2 is a well-established neuronal stem cell-associated transcription factor that regulates neural development and adult neurogenesis in vertebrates, and is one of the critical genes used to reprogram differentiated cells into induced pluripotent stem cells. We examined if Sox2 was involved in the early reprogramming-like events that Müller glia undergo as they upregulate many pluripotency- and neural stem cell-associated genes required for proliferation in light-damaged adult zebrafish reti…

    Date Published:
    2017-08
  • Author(s):
    Paul T. Kroeger, Bridgette E. Drumond, Rachel Miceli, Michael McKernan, Gary F. Gerlach, Amanda N. Marra, Annemarie Fox, Kristen K. McCampbell, Ignaty Leshchiner, Adriana Rodriguez-Mari, Ruth Bremiller, Ryan Thummel, Alan J. Davidson, John Postlethwait, Wolfram Goessling, Rebecca Wingert
    Abstract:

    The zebrafish kidney is conserved with other vertebrates, making it an excellent genetic model to study renal development. The kidney collects metabolic waste using a blood filter with specialized epithelial cells known as podocytes. Podocyte formation is poorly understood but relevant to many kidney diseases, as podocyte injury leads to progressive scarring and organ failure. zeppelin (zep) was isolated in a forward screen for kidney mutants and identified as a homozygous recessive lethal al…

    Date Published:
    2017