Search CurateND

Filter by:

Search criteria:

Department or Unit: Centers and Institutes remove × Department or Unit: Biological Sciences remove × Department or Unit: Notre Dame Research remove × Academic Status: Faculty remove × Creator: Yong Cheng remove × Language: English remove × Publisher: Cold Sring Harbor Laboratory remove × Type of Work: Article remove ×
Clear all
1 entry found

List of files deposited in CurateND that match your search criteria

  • 1

    Article

    Extracellular Vesicles promote host immunity during an M. tuberculosis infection through RNA Sensing
    Thumbnail
    Author(s):
    Jeff Schorey, Yong Cheng
    Abstract:

    Extracellular vesicles (EVs) have been shown to carry microbial components and function in the host defense against infections. In this study, we demonstrate that Mycobacterium tuberculosis (M.tb) RNA is delivered into macrophage-derived EVs through an M.tb SecA2-dependent pathway, and that EVs released from M.tb-infected macrophages stimulate a host RIG-I/MAVS/TBK1/IRF3 RNA sensing pathway, leading to type I interferon production in recipient cells. These EVs also promote, in a RIG-I/MAVS-de…

    Date Published:
    2018-06
    Record Visibility:
    Public
1 entry found