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  • Author(s):
    Matthew Sisk
    Abstract:

    Lead exposure is a major health hazard affecting children and their growth and is a concern in many urban areas around the world. One such city in the United States (US), South Bend Indiana, gained attention for its high levels of lead in blood and relatively low testing rates for children. We assessed current lead screening practices in South Bend and the surrounding St. Joseph County (SJC). The 2005–2015 lead screening data included 18,526 unique children. Lead screening rates ranged from 4…

  • Author(s):
    Md Suhail Alam, Bruce Cooper, Kasturi Halder
    Abstract:

    Histone deacetylase (HDAC) inhibitors are of significant interest as drugs. However, their use in neurological disorders has raised concern because HDACs are required for brain function. We have previously shown that a triple combination formulation (TCF) of the pan HDACi vorinostat (Vo) improves pharmacokinetic exposure and entry of Vo into the brain. TCF treatment significantly delayed both neurodegeneration and death in the Npc1nmf164 murine model of Niemann Pick Type C (NPC) disease. The …

    Date Published:
    2017-09
  • Author(s):
    Manuela Lahne, Clare E. Yarka, Michael E. Petravick, Jingling Li, David R. Hyde
    Abstract:

    Sox2 is a well-established neuronal stem cell-associated transcription factor that regulates neural development and adult neurogenesis in vertebrates, and is one of the critical genes used to reprogram differentiated cells into induced pluripotent stem cells. We examined if Sox2 was involved in the early reprogramming-like events that Müller glia undergo as they upregulate many pluripotency- and neural stem cell-associated genes required for proliferation in light-damaged adult zebrafish reti…

    Date Published:
    2017-08
  • Author(s):
    Jeff Schorey, Yong Cheng
    Abstract:

    Extracellular vesicles (EVs) have been shown to carry microbial components and function in the host defense against infections. In this study, we demonstrate that Mycobacterium tuberculosis (M.tb) RNA is delivered into macrophage-derived EVs through an M.tb SecA2-dependent pathway, and that EVs released from M.tb-infected macrophages stimulate a host RIG-I/MAVS/TBK1/IRF3 RNA sensing pathway, leading to type I interferon production in recipient cells. These EVs also promote, in a RIG-I/MAVS-de…

    Date Published:
    2018-06
  • Author(s):
    Paul T. Kroeger, Bridgette E. Drumond, Rachel Miceli, Michael McKernan, Gary F. Gerlach, Amanda N. Marra, Annemarie Fox, Kristen K. McCampbell, Ignaty Leshchiner, Adriana Rodriguez-Mari, Ruth Bremiller, Ryan Thummel, Alan J. Davidson, John Postlethwait, Wolfram Goessling, Rebecca Wingert
    Abstract:

    The zebrafish kidney is conserved with other vertebrates, making it an excellent genetic model to study renal development. The kidney collects metabolic waste using a blood filter with specialized epithelial cells known as podocytes. Podocyte formation is poorly understood but relevant to many kidney diseases, as podocyte injury leads to progressive scarring and organ failure. zeppelin (zep) was isolated in a forward screen for kidney mutants and identified as a homozygous recessive lethal al…

    Date Published:
    2017
  • Author(s):
    Matthew Sisk, Lacey Ahern, Heidi Beidinger, Danielle LaFleur, Michelle Ngai
    Abstract:

    Lead exposure in SJC continues to be a persistent, complex public health issue. Data released in December 2016 showed that census tract 6 in South Bend had the highest rates of EBLL in the state of Indiana. Because lead exposure can produce significant cognitive and physiological damage even at very low levels of exposure, immediate action was required. Understanding what the epidemiologic profile of lead in SJC was among the first steps taken to address this issue. The St. Joseph Coun…

    Date Published:
    2017-07
  • Author(s):
    Julie Braungart-Rieker, Elizabeth Moore, Jen Burke Lefever, Kathy Guajardo
    Abstract:

    Obesity rates in the U.S. for both children and adults are alarmingly high, particularly for those in low-income households. The current project, a partnership between Elkhart and St. Joseph Counties Head Start Consortium and the University of Notre Dame’s William J. Shaw Center for Children and Families, focused on reducing obesogenic home environments for low-income families. Focusing on home environments, particularly for young children, is important because research shows that mothers are…

    Date Created:
    2017-10-31
    Resource Type
    Report
  • Author(s):
    Robert Johansen, Alexander Dukalskis
    Abstract:

    Developing normative indicators to measure governments’ consent to, compliance with, and promotion of international laws prohibiting genocide, war crimes, crimes against humanity, and other norms constituting the International Criminal Court (ICC) demonstrates that it is possible to calibrate variation in state conduct over time and to compare one state to another. The indicators make compliance more visible and amenable, both to encouragement by nongovernmental organizations and states, and …

    Date Published:
    2013
  • Author(s):
    Michel Hockx
    Subject(s):
    Chinese poetry--20th century--History and criticism
    Abstract:

    Literary historians tend to deal with China’s earliest ‘new poets’ with scant regard. These poets are thought to have been the experimenters, the forerunners whose only task it was to fail so that others might succeed. Their pluriform and many-sided work is consequently only discussed in footnotes and introductory chapters.

    Focusing on the poetry and poetics of the eight authors of A Snowy Morning (1922), and on contemporary and modern reception of their work, the present study…

    Date Published:
    1994
    Resource Type
    Book
  • Author(s):
    Matthew Sisk, Danielle Wood
    Abstract:

    Community-Based Research is a collaborative approach to research where academic researchers, community members, and organizations are involved in the development, implementation and dissemination of research. Such projects are often designed to promote positive change in particular areas of the community. Here we report on a two-year old community-based research project through the University of Notre Dame’s Center for Digital Scholarship and Center for Social Concerns. Working with the…

  • Abstract:

    The Badin Bible, a 1790 Mathew Carey Douay-Rheims Bible in English published in Philadelphia, was acquired by the Special Collections department of the Hesburgh Libraries in July 2014. The Bible was likely a gift from Bishop John Carroll to Stephen Badin on the occasion of his ordination to the priesthood in 1793. Badin later served as a missionary in Kentucky, Indiana, Illinois, and Michigan. He ministered to Native Americans in northern Indiana, and purchased the land that now is the Univer…

    Date Created:
    2014-11-05
    Resource Type
    Document
  • Author(s):
    Eric Lease Morgan, Xiaorong Xiang
    Abstract:

    This article describes the design and implementation of two digital library collections and services using a number of “light-weight” protocols and open source tools. These protocols and tools include OAI-PMH (Open Archives Initiative-Protocol for Metadata Harvesting), SRU (Search/Retrieve via URL), Perl, MyLibrary, Swish-e, Plucene, ASPELL, and WordNet. More specifically, we describe how these protocols and tools are employed in the Ockham Alerting service and MyLibrary@Ockham. The…