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  • Author(s):
    Matthew Sisk
    Abstract:

    Lead exposure is a major health hazard affecting children and their growth and is a concern in many urban areas around the world. One such city in the United States (US), South Bend Indiana, gained attention for its high levels of lead in blood and relatively low testing rates for children. We assessed current lead screening practices in South Bend and the surrounding St. Joseph County (SJC). The 2005–2015 lead screening data included 18,526 unique children. Lead screening rates ranged from 4…

    Record Visibility:
    Public
  • Author(s):
    Md Suhail Alam, Bruce Cooper, Kasturi Halder
    Abstract:

    Histone deacetylase (HDAC) inhibitors are of significant interest as drugs. However, their use in neurological disorders has raised concern because HDACs are required for brain function. We have previously shown that a triple combination formulation (TCF) of the pan HDACi vorinostat (Vo) improves pharmacokinetic exposure and entry of Vo into the brain. TCF treatment significantly delayed both neurodegeneration and death in the Npc1nmf164 murine model of Niemann Pick Type C (NPC) disease. The …

    Date Published:
    2017-09
    Record Visibility:
    Public
  • Author(s):
    Manuela Lahne, Clare E. Yarka, Michael E. Petravick, Jingling Li, David R. Hyde
    Abstract:

    Sox2 is a well-established neuronal stem cell-associated transcription factor that regulates neural development and adult neurogenesis in vertebrates, and is one of the critical genes used to reprogram differentiated cells into induced pluripotent stem cells. We examined if Sox2 was involved in the early reprogramming-like events that Müller glia undergo as they upregulate many pluripotency- and neural stem cell-associated genes required for proliferation in light-damaged adult zebrafish reti…

    Date Published:
    2017-08
    Record Visibility:
    Public
  • Author(s):
    Jeff Schorey, Yong Cheng
    Abstract:

    Extracellular vesicles (EVs) have been shown to carry microbial components and function in the host defense against infections. In this study, we demonstrate that Mycobacterium tuberculosis (M.tb) RNA is delivered into macrophage-derived EVs through an M.tb SecA2-dependent pathway, and that EVs released from M.tb-infected macrophages stimulate a host RIG-I/MAVS/TBK1/IRF3 RNA sensing pathway, leading to type I interferon production in recipient cells. These EVs also promote, in a RIG-I/MAVS-de…

    Date Published:
    2018-06
    Record Visibility:
    Public
  • Author(s):
    Paul T. Kroeger, Bridgette E. Drumond, Rachel Miceli, Michael McKernan, Gary F. Gerlach, Amanda N. Marra, Annemarie Fox, Kristen K. McCampbell, Ignaty Leshchiner, Adriana Rodriguez-Mari, Ruth Bremiller, Ryan Thummel, Alan J. Davidson, John Postlethwait, Wolfram Goessling, Rebecca Wingert
    Abstract:

    The zebrafish kidney is conserved with other vertebrates, making it an excellent genetic model to study renal development. The kidney collects metabolic waste using a blood filter with specialized epithelial cells known as podocytes. Podocyte formation is poorly understood but relevant to many kidney diseases, as podocyte injury leads to progressive scarring and organ failure. zeppelin (zep) was isolated in a forward screen for kidney mutants and identified as a homozygous recessive lethal al…

    Date Published:
    2017
    Record Visibility:
    Public
  • Author(s):
    Matthew Sisk, Lacey Ahern, Heidi Beidinger, Danielle LaFleur, Michelle Ngai
    Abstract:

    Lead exposure in SJC continues to be a persistent, complex public health issue. Data released in December 2016 showed that census tract 6 in South Bend had the highest rates of EBLL in the state of Indiana. Because lead exposure can produce significant cognitive and physiological damage even at very low levels of exposure, immediate action was required. Understanding what the epidemiologic profile of lead in SJC was among the first steps taken to address this issue. The St. Joseph Coun…

    Date Published:
    2017-07
    Record Visibility:
    Public
  • Author(s):
    Robert Johansen, Alexander Dukalskis
    Abstract:

    Developing normative indicators to measure governments’ consent to, compliance with, and promotion of international laws prohibiting genocide, war crimes, crimes against humanity, and other norms constituting the International Criminal Court (ICC) demonstrates that it is possible to calibrate variation in state conduct over time and to compare one state to another. The indicators make compliance more visible and amenable, both to encouragement by nongovernmental organizations and states, and …

    Date Published:
    2013
    Record Visibility:
    Public
  • 8

    Video

    Description(s):
    Oral History Interview with Gloria Molina, intervewed by Luis Fraga
    Interviewer(s):
    Luis Fraga
    Interviewee(s):
    Gloria Molina
    Date Published:
    2017-03-08
    Record Visibility:
    Public
  • Description(s):
    Oral History Interview with writer Rigoberto Gonzalez, interviewed by Francisco Aragón
    Interviewer(s):
    Francisco Aragón
    Interviewee(s):
    Rigoberto Gonzalez
    Date Published:
    2017-04-19
    Record Visibility:
    Public
  • Description(s):
    Oral history interview with sculptor, muralist, singer and musician Adolfo "Zarco" Guerrero, interviewed by Brookes Ebetsch.
    Interviewer(s):
    Brookes Ebetsch
    Interviewee(s):
    Adolfo "Zarco" Guerrero
    Date Published:
    2005-11-01
    Record Visibility:
    Public
  • 11

    Video

    Description(s):
    Oral history interview with painter Alfredo Arreguin, interviewed by Brookes Ebetsch and Amelia Malagamba.
    Interviewer(s):
    Bookes Ebetsch, Amelia Malagamba
    Interviewee(s):
    Alfredo Arreguin
    Date Published:
    2005-06-12
    Record Visibility:
    Public
  • 12

    Video

    Description(s):
    Oral history interview with curator and art historian Andrew Connors, interviewed by Brookes Ebetsch.
    Interviewer(s):
    Brookes Ebetsch
    Interviewee(s):
    Andrew Connors
    Date Published:
    2005-11-11
    Record Visibility:
    Public