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  • Author(s):
    Jeff Schorey, Yong Cheng
    Abstract:

    Extracellular vesicles (EVs) have been shown to carry microbial components and function in the host defense against infections. In this study, we demonstrate that Mycobacterium tuberculosis (M.tb) RNA is delivered into macrophage-derived EVs through an M.tb SecA2-dependent pathway, and that EVs released from M.tb-infected macrophages stimulate a host RIG-I/MAVS/TBK1/IRF3 RNA sensing pathway, leading to type I interferon production in recipient cells. These EVs also promote, in a RIG-I/MAVS-de…

    Date Published:
    2018-06
  • Author(s):
    Paul T. Kroeger, Bridgette E. Drumond, Rachel Miceli, Michael McKernan, Gary F. Gerlach, Amanda N. Marra, Annemarie Fox, Kristen K. McCampbell, Ignaty Leshchiner, Adriana Rodriguez-Mari, Ruth Bremiller, Ryan Thummel, Alan J. Davidson, John Postlethwait, Wolfram Goessling, Rebecca Wingert
    Abstract:

    The zebrafish kidney is conserved with other vertebrates, making it an excellent genetic model to study renal development. The kidney collects metabolic waste using a blood filter with specialized epithelial cells known as podocytes. Podocyte formation is poorly understood but relevant to many kidney diseases, as podocyte injury leads to progressive scarring and organ failure. zeppelin (zep) was isolated in a forward screen for kidney mutants and identified as a homozygous recessive lethal al…

    Date Published:
    2017
  • Author:
    Sarah E. Naramore
    Advisory Committee:
    Christopher Hamlin
    Degree Area:
    History and Philosophy of Science
    Degree:
    PhD
    Defense Date:
    2018-04-24
  • Author:
    Heather M. DuBois
    Advisory Committee:
    Atalia Omer, J. Matthew Ashley, M. Catherine Hilkert, R. Scott Appleby, Keith J. Egan
    Degree Area:
    Peace Studies
    Degree:
    PhD
    Defense Date:
    2018-05-15
  • Author:
    Leo Guardado
    Advisory Committee:
    Timothy Matovina, Mary Catherine Hilkert, O.P., Kraig Beyerlein, John Paul Lederach, Gustavo Gutierrez
    Degree Area:
    Peace Studies, Theology
    Degree:
    PhD
    Defense Date:
    2018-04-03
  • Author:
    Matthew J. Chandler
    Advisory Committee:
    Ann Mische
    Degree Area:
    Peace Studies
    Degree:
    PhD
    Defense Date:
    2017-12-13
  • Author:
    Christopher R. J. Scheirer
    Advisory Committee:
    Christopher Abram
    Degree Area:
    Medieval Studies
    Degree:
    PhD
    Defense Date:
    2017-11-02
  • Author:
    Brandon LeVon Cook
    Advisory Committee:
    Danielle Joyner, Michael Schreffler, Jacqueline Jung, Richard Cross
    Degree Area:
    Medieval Studies
    Degree:
    PhD
    Defense Date:
    2017-07-10
  • Author(s):
    Matthew Sisk, Lacey Ahern, Heidi Beidinger, Danielle LaFleur, Michelle Ngai
    Abstract:

    Lead exposure in SJC continues to be a persistent, complex public health issue. Data released in December 2016 showed that census tract 6 in South Bend had the highest rates of EBLL in the state of Indiana. Because lead exposure can produce significant cognitive and physiological damage even at very low levels of exposure, immediate action was required. Understanding what the epidemiologic profile of lead in SJC was among the first steps taken to address this issue. The St. Joseph Coun…

    Date Published:
    2017-07
  • Author(s):
    Julie Braungart-Rieker, Elizabeth Moore, Jen Burke Lefever, Kathy Guajardo
    Abstract:

    Obesity rates in the U.S. for both children and adults are alarmingly high, particularly for those in low-income households. The current project, a partnership between Elkhart and St. Joseph Counties Head Start Consortium and the University of Notre Dame’s William J. Shaw Center for Children and Families, focused on reducing obesogenic home environments for low-income families. Focusing on home environments, particularly for young children, is important because research shows that mothers are…

    Date Created:
    2017-10-31
    Resource Type
    Report
  • Creator(s):
    Edward Beatty
    Description:

    The Mexican patent database collects data on all patents issued in Mexico from roughly 1840 to the onset of the Mexican Revolution in 1911, totaling approximately thirteen thousand five hundred (13,500) discrete patent records. At present, this is the most comprehensive record of patents issued by Mexican governments during the nineteenth century. There is no single archival or published source that contains a comprehensive list or data on Mexican patents issued over the course of the long …

    Date Created:
    2018-01-29
  • Author:
    Jessica A. Brandwein
    Advisory Committee:
    Patrick Regan, Peter Wallensteen, Ernesto Verdeja, Christian Davenport
    Degree Area:
    Peace Studies, Political Science
    Degree:
    PhD
    Defense Date:
    2017-07-27