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  • Author(s):
    Jane Cleland-Huang, Michael Vierhauser
    Abstract:

    Traditionally, safety-critical projects have been developed using the waterfall process. However, this makes it costly and challenging to incrementally introduce new features and to certify the modified product for use. As a result, there has been increasing interest in adopting agile development paradigms within the safety-critical domain. This in turn introduces numerous challenges. In this paper we address the specific problems of discovering, analyzing, specifying, and managing safety req…

    Date Published:
    2018-08
  • Author:
    Gerardo Silva-Oelker
    Advisory Committee:
    Patrick Fay
    Degree Area:
    Electrical Engineering
    Degree:
    Doctor of Philosophy
    Defense Date:
    2019-01-15
  • Author:
    Joshua D Szczudlak
    Advisory Committee:
    Scott C. Morris, Aleks Jemcov
    Degree Area:
    Aerospace and Mechanical Engineering
    Degree:
    Doctor of Philosophy
    Defense Date:
    2019-01-23
  • Author:
    Andrew Bartolini
    Advisory Committee:
    Tracy Kijewski-Correa, Ahsan Kareem, Alexandros Taflanidis, Dae Kun Kwon
    Degree Area:
    Civil and Environmental Engineering and Earth Sciences
    Degree:
    Doctor of Philosophy
    Defense Date:
    2018-12-07
  • Author:
    Jorge Morales Ferreiro
    Advisory Committee:
    Donovan Diaz Droguett, Yanliang Zhang, David Go, Tengfei Luo, Magdalena Walczak, Diego Celentano
    Degree Area:
    Aerospace and Mechanical Engineering
    Degree:
    Doctor of Philosophy
    Defense Date:
    2018-09-27
  • Author(s):
    Yide Zhang
    Abstract:

    Multiphoton microscopy combined with fluorescence lifetime imaging microscopy (MPM-FLIM) is a technique that allows for imaging the lifetime of fluorescence created by two-photon excitation. It not only possesses the advantages of MPM such as large imaging depth, but also the strengths of FLIM including the ability to discriminate different fluorophores with similar emission spectra. In FLIM, the frequency-domain (FD) method, which relies on periodic intensity-modulated excitation light and i…

    Date Created:
    2015-10-22
    Resource Type
    Presentation
  • Author(s):
    Yide Zhang
    Abstract:

    In cancer and all biomedical researches, we always need a microscope with better imaging precision, speed, functionality, and depth, so that the diagnostics and treatments of cancer and other diseases can be accurate, fast, and noninvasive. However, conventional fluorescence microscopes cannot satisfy these needs due to physical limits on resolution, speed, information, and depth. In this work, we aim to overcome these limits using novel super-resolution microscopy and high-speed quantitative…

    Date Created:
    2018-04-09
    Resource Type
    Presentation
  • Author(s):
    Yide Zhang
    Abstract:

    Multiphoton microscopy (MPM) is a widely used in vivo imaging technique in biological and medical applications. In the case of two-photon excitation fluorescence, two lower-energy photons excite a fluorophore which in turn emits a single higher-energy photon, whose rate depends quadratically on the excitation intensity, thus enabling higher resolution with narrower point spread function (PSF) than conventional one-photon fluorescence microscopy. Fluorescence lifetime imaging microscopy (FLIM)…

    Date Created:
    2016-04-04
    Resource Type
    Presentation
  • Author(s):
    Yide Zhang
    Abstract:

    To fundamentally understand biological and medical phenomena such as aging and diseases, we need the information of the microenvironment surrounding living cells. We propose the multiphoton fluorescence lifetime imaging microscopy (MPM-FLIM) platform with super-sensitivity and super-resolution capabilities to quantitatively obtain this information at the intracellular level. First, we present a simple MPM oxygen imaging probe compatible with aqueous biological media based on water-soluble rut…

    Date Created:
    2017-03-30
    Resource Type
    Presentation
  • Author(s):
    Yide Zhang
    Abstract:

    Super-resolution fluorescence microscopy is an important tool in biomedical research for its ability to discern features smaller than the diffraction limit, but its universal application is not feasible due to its difficult implementation and high cost. In this research, we propose and demonstrate a new kind of super-resolution fluorescence microscopy that can be easily implemented and requires neither additional hardware nor complex post-processing. The microscopy is based on the principle o…

    Date Created:
    2017-10-19
    Resource Type
    Presentation
  • Author(s):
    Yide Zhang, Scott S. Howard, Cody J. Smith
    Abstract:

    Super-resolution microscopy is broadening our in-depth understanding of cellular structure. However, super-resolution approaches are limited, for numerous reasons, from utilization in longer-term intravital imaging. We devised a combinatorial imaging technique that combines deconvolution with stepwise optical saturation microscopy (DeSOS) to circumvent this issue and image cells in their native physiological environment. Other than a traditional confocal or two-photon microscope, this approac…

    Date Created:
    2019-01-09
    Resource Type
    Software
  • Author(s):
    Michael Vierhauser, Jane Cleland-Huang, Rick Rabiser, Thomas Krismayer, Paul Grünbacher
    Abstract:

    Industrial software systems are often systems of systems~(SoS) whose full behavior only emerges during operation. They therefore require monitoring techniques to observe systems and detect deviations from their requirements. The focus of existing monitoring approaches, however, is mainly on detecting violations of expected behavior, while support for diagnosing violations is typically limited or even neglected. Diagnosis is particularly challenging in SoS due to their technological heterogene…

    Date Published:
    2018-08