Aerospace and Mechanical Engineering

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  • Author(s):
    Cody E. Narcisco, Nicholas M. Contento, Thomas J. Storey, David J. Hoelzle, Jeremiah J. Zartman

    Mechanical forces are critical but poorly understood inputs for organogenesis and wound healing. Calcium ions (Ca2+) are critical second messengers in cells for integrating environmental and mechanical cues, but the regulation of Ca2+ signaling is poorly understood in developing epithelial tissues. Here we report a chip-based regulated environment for microorgans that enables systematic investigations of the crosstalk between an organ’s mechanical stress environment and biochemical signaling …

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