Aerospace and Mechanical Engineering

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  Article

  Release of Applied Mechanical Loading Stimulates Intercellular Calcium Waves in Drosophila Wing Discs
  

  Author(s):

  Cody E. Narcisco, Nicholas M. Contento, Thomas J. Storey, David J. Hoelzle, Jeremiah J. Zartman

  Abstract:

  Mechanical forces are critical but poorly understood inputs for organogenesis and wound healing. Calcium ions (Ca2+) are critical second messengers in cells for integrating environmental and mechanical cues, but the regulation of Ca2+ signaling is poorly understood in developing epithelial tissues. Here we report a chip-based regulated environment for microorgans that enables systematic investigations of the crosstalk between an organ’s mechanical stress environment and biochemical signaling …

  Date Published:

  2017-07

  Record Visibility:

  Public