Aerospace and Mechanical Engineering

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  • Author(s):
    Bradley Ellis, Aylin Acun, U. Isik Can, Pinar Zorlutuna
    Abstract:

    The heart wall tissue, or the myocardium, is one of the main targets in cardiovascular disease prevention and treatment. Animal models have not been sufficient in mimicking the human myocardium as evident by the very low clinical translation rates of cardiovascular drugs. Additionally, current in vitro models of the human myocardium possess several shortcomings such as lack of physiologically relevant co-culture of myocardial cells, lack of a 3D biomimetic environment, and the use of non-huma…

    Date Published:
    2017-03
  • Author(s):
    Shirou Lou, Jarrod Schiffbauer, Tengfei Lou
    Abstract:

    In this work, the droplet size in a water-in-oil emulsion obtained by supersaturation is studied. The emulsion is obtained by cooling down a saturated water/oil solution by a certain temperature difference. The effects of the cooling rate and temperature difference on the produced droplet size are experimentally investigated. The average size of water droplets in the emulsion is found to be proportional to the square root of the cooling rate. By analyzing the time scales of three different st…

    Date Published:
    2017-10
  • Author(s):
    Yide Zhang, Prakash Nallathamby, Genevieve D. Vigil, Aamir A. Khan, Devon E. Mason, Joel D. Boerckel, Ryan K. Roeder, Scott S. Howard
    Abstract:

    Super-resolution fluorescence microscopy is an important tool in biomedical research for its ability to discern features smaller than the diffraction limit. However, due to its difficult implementation and high cost, the super-resolution microscopy is not feasible in many applications. In this paper, we propose and demonstrate a saturation-based super-resolution fluorescence microscopy technique that can be easily implemented and requires neither additional hardware nor complex post-processin…

    Date Published:
    2018-04
  • Author(s):
    Cody E. Narcisco, Nicholas M. Contento, Thomas J. Storey, David J. Hoelzle, Jeremiah J. Zartman
    Abstract:

    Mechanical forces are critical but poorly understood inputs for organogenesis and wound healing. Calcium ions (Ca2+) are critical second messengers in cells for integrating environmental and mechanical cues, but the regulation of Ca2+ signaling is poorly understood in developing epithelial tissues. Here we report a chip-based regulated environment for microorgans that enables systematic investigations of the crosstalk between an organ’s mechanical stress environment and biochemical signaling …

    Date Published:
    2017-07
  • Inventor(s):
    Abhay Kumar, Paul W. Futa, Jr., Steven F. Fisher
    Patent Number:
    US 6328056 B2
    Description:

    An unbalance compensated bypass valve (14, 21, 23) for a gas turbine engine fuel supply system is responsive to the fuel pressure differential across a fuel metering valve (15) to open and close a bypass orifice (37, 39, 41; 89, 91, 93; 99, 101, 103). The bypass valve (14, 21, 23) selectively supplies high fuel pressure to a compensating cavity (45, 95, 120) providing a counterbalancing force against an annular area (47, 97, 124) of the bypass valve piston (34, 81, 83, 111, 112) to compensate…

    Date Issued:
    2001-12-11
    Resource Type
    Patent
  • Inventor(s):
    Timothy C. Ovaert
    Patent Number:
    US 8919066 B2
    Description:

    An apparatus including an impact surface and a plurality of spaced apart stiffening columns extending from an underside of the flooring plate. The columns remain substantially rigid up to a predetermined critical pressure and then buckle as the pressure increases. The columns are at least partially surrounded by a resilient underlayment. Deflection stops may extend from the flooring plate to prevent over-buckling and/or permanent deformation of the stiffening columns. In some examples, the de…

    Date Issued:
    2014-12-30
    Resource Type
    Patent
  • Inventor(s):
    Mehul Patel, Thomas C. Corke, Alan B. Cain
    Patent Number:
    US 9541106 B1
    Description:

    The present invention relates to a method of designing or optimizing a control surface for use with plasma actuators for controlling an aircraft, missile, munition or automobile, and more particularly to controlling fluid flow across their surfaces or other surfaces using plasma actuators, which would benefit from such a method. The various embodiments provide the steps to increase the efficiency of aircraft, missiles, munitions and automobiles. The method of flow control also provides a mean…

    Date Issued:
    2017-01-10
    Resource Type
    Patent
  • Inventor(s):
    Ryan K. Roeder, Matthew J. Meagher, Robert J. Kane
    Patent Number:
    US 9550012 B2
    Description:

    The invention provides a novel composite bone graft system utilizing a porous collagen scaffold having a matrix impregnated with calcium phosphate particles and more than one bioactive agent, one of which is conjugated to the matrix. The graft system exhibits increased mechanical strength and osteogenic properties by providing sites for tissue attachment and propagation. The bioactive agents are delivered to the scaffold via different mechanisms to enable sequential and sustained release of t…

    Date Issued:
    2017-01-24
    Resource Type
    Patent
  • Inventor(s):
    Nishant Chetwani, Catherine Cassou, David Go, Hsueh-Chia Chang
    Patent Number:
    US 8716675 B2
    Description:

    An alternating current electrospray mass spectrometry device includes an electrospray device having at least one emitter providing a passageway for transmission of an analyte sample. At least one conductive element is in electrical communication with the at least one emitter. A power source generates an alternating current electric field to form a liquid cone at a tip of the emitter and ionizes the analyte sample present in the liquid cone. The frequency of the electric field entrains low mob…

    Date Issued:
    2014-05-06
    Resource Type
    Patent
  • Inventor(s):
    Kishore K. Pydimarry, Duane T. Detwiler, John E. Renaud, Neal M. Patel, Byungsoo Kang, Chandan K. Mozumder
    Patent Number:
    US 8880380 B2
    Description:

    Crashworthiness designing of a structure using a Hybrid Cellular Automata (HCA) algorithm where field states are computed using finite element analysis (FEA) and the material distribution of the structure is updated at each iteration using cellular automata method. The HCA algorithm optimizes the topology of the structures to achieve certain performance within the limits of various constraints applied to ensure crashworthiness of the structures. The HCA algorithm may also be applied to design…

    Date Issued:
    2014-11-04
    Resource Type
    Patent
  • Inventor(s):
    Fabio Semperlotti, Hongfei Zhu
    Patent Number:
    US 9437183 B2
    Description:

    An embedded acoustic metamaterial lenses allows for ultrasonic beam-forming and high resolution identification of acoustic sources for structural health monitoring. The lenses design provides an alternative to conventional phased-array technology enabling the formation of steerable and collimated (or focused) ultrasonic beams by exploiting a single transducer. The ultrasonic beam can be steered by simply tuning the frequency of the excitation. Also, the embedded lens can be designed to achiev…

    Date Issued:
    2016-09-06
    Resource Type
    Patent
  • Inventor(s):
    Thomas C. Corke, Mehul Patel
    Patent Number:
    US 9,834,301 B1
    Description:

    A method of increasing the performance of an aircraft, missile, munition or ground vehicle with plasma actuators, and more particularly of controlling fluid flow across their surfaces or other surfaces which would benefit from such a method, includes the design of an aerodynamic plasma actuator for the purpose of controlling airflow separation over a control surface of a aircraft, missile, or a ground vehicle, and a method of determining a modulation frequency for the plasma actuator for the …

    Date Issued:
    2017-12-05
    Resource Type
    Patent