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  • Author(s):
    Cody E. Narcisco, Nicholas M. Contento, Thomas J. Storey, David J. Hoelzle, Jeremiah J. Zartman
    Abstract:

    Mechanical forces are critical but poorly understood inputs for organogenesis and wound healing. Calcium ions (Ca2+) are critical second messengers in cells for integrating environmental and mechanical cues, but the regulation of Ca2+ signaling is poorly understood in developing epithelial tissues. Here we report a chip-based regulated environment for microorgans that enables systematic investigations of the crosstalk between an organ’s mechanical stress environment and biochemical signaling …

    Date Published:
    2017-07
  • Inventor(s):
    Hsueh-Chia Chang, David T. Leighton
    Patent Number:
    US 6428754 B2
    Description:

    An exhaust gas treatment system and method for treating the exhaust gas of an internal combustion engine includes a catalytic converter and a catalytic preheater or igniter upstream of the catalytic converter. A bypass passage extends around the igniter such that during the ignition period about two-thirds of the exhaust gas is bypassed around the igniter and one-third passes through the igniter. The igniter raises the temperature of the exhaust gases passing therethrough to an adiabatic temp…

    Date Issued:
    2002-08-06
    Resource Type
    Patent
  • Inventor(s):
    Hsueh-Chia Chang, Shau-Chun Paul Wang, Dmitri Lastochkin, Leslie Yeo, Zachary Gagnon
    Patent Number:
    US 8267914 B1
    Description:

    The present invention provides an electrospray device using a high frequency alternating current (AC) above 10 kHz to generate fine micron sized drops. The apparatus generally functions by applying a high frequency alternating current electric field across one or more micro-needles and one or more conducting elements. The present invention may be used to generate aerosol drops for respiratory drug delivery or as a microencapsulation technique for the encapsulation of drugs, DNA, protein, oste…

    Date Issued:
    2012-09-18
    Resource Type
    Patent
  • Inventor(s):
    Hsueh-Chia Chang, Zilin Chen, Fu-Chih Hsu, David Battigelli
    Patent Number:
    US 7960180 B2
    Description:

    Methods and apparatus to capture and release microbe particles using amino-functionalized silica substrates are described. An example apparatus adapted to capture a microbe particle includes a silica substrate and a positively charged material to at least partially coat the silica substrate. The positive charged material includes an aminopropyl functional group.

    Date Issued:
    2011-06-14
    Resource Type
    Patent
  • Inventor(s):
    Zachary Gagnon, Hsueh-Chia Chang
    Patent Number:
    US 7744738 B2
    Description:

    The present invention provides a method and apparatus for use in rapid particle transportation, separation, focusing, characterization, and release. Dielectrophoresis and electro-osmotic driven fluid convection are used independently or in tandem as the driving forces for particle manipulation and on occasion characterization. Although dielectrophoresis has been acknowledged for decades as a powerful technique for particle manipulation and characterization, long processing times and measureme…

    Date Issued:
    2010-06-29
    Resource Type
    Patent
  • Inventor(s):
    Nishant Chetwani, Catherine Cassou, David Go, Hsueh-Chia Chang
    Patent Number:
    US 8716675 B2
    Description:

    An alternating current electrospray mass spectrometry device includes an electrospray device having at least one emitter providing a passageway for transmission of an analyte sample. At least one conductive element is in electrical communication with the at least one emitter. A power source generates an alternating current electric field to form a liquid cone at a tip of the emitter and ionizes the analyte sample present in the liquid cone. The frequency of the electric field entrains low mob…

    Date Issued:
    2014-05-06
    Resource Type
    Patent
  • Inventor(s):
    Siyuan Zhang, Jeremiah Zartman, David Hoelzle, Cody Narciso
    Patent Number:
    US 9975121 B2
    Description:

    A microfluidic device for evaluating a tissue sample can include a tissue chamber, a liquid inlet channel, a liquid outlet channel, and at least one of components (1)-(3). The tissue chamber can be defined by a plurality of walls, at least one of which is transparent. The liquid inlet and outlet channels can be in fluid communication with the tissue chamber. Components (1)-(3) can include: (1) a deformable membrane disposed within the tissue chamber and being configured to oscillate, upon app…

    Date Issued:
    2018-05-22
    Resource Type
    Patent
  • Inventor(s):
    Jeremiah Zartman, David Hoelzle, Cody Narciso, Siyuan Zhang, Wendy Alvarez Barrios, Victoria Zellmer
    Patent Number:
    US 10168259 B2
    Description:

    One aspect of the present disclosure can include a microfluidic device for imaging a tissue sample. The device can include a tissue chamber, a liquid inlet channel, and a liquid outlet channel. The tissue chamber can be defined by a plurality of walls, at least one of which is transparent. The liquid inlet channel can be fluid communication with the tissue chamber. The liquid outlet channel can be in fluid communication with the tissue chamber. The tissue chamber can be sized and dimensioned …

    Date Issued:
    2019-01-01
    Resource Type
    Patent