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    Patent

    Multifunctional micellar nanoparticle-based drug and targeting agent system
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    Inventor(s):
    Z. Basar Bilgicer, Tanyel Kiziltepe Bilgicer, Jonathan D. Ashley, Jared Stefanick, Nathan J. Alves, Michael W. Handlogten
    Patent Number:
    US 9872870 B2
    Description:

    Embodiments provide systems, methods, and compositions for nanoparticle-based drug delivery to target cells or tissues. A drug delivery system may include a nanoparticle with a targeting component and a therapeutic component. The nanoparticle may have a predetermined number or valence of targeting molecules for multivalent interaction with a target cell or tissue. Binding of the targeting molecules to the target cell may result in receptor-mediated uptake of the nanoparticle by the target cel…

    Date Issued:
    2018-01-23
    Record Visibility:
    Public
    Title
    Multifunctional micellar nanoparticle-based drug and targeting agent system
    Description
    Embodiments provide systems, methods, and compositions for nanoparticle-based drug delivery to target cells or tissues. A drug delivery system may include a nanoparticle with a targeting component and a therapeutic component. The nanoparticle may have a predetermined number or valence of targeting molecules for multivalent interaction with a target cell or tissue. Binding of the targeting molecules to the target cell may result in receptor-mediated uptake of the nanoparticle by the target cell. The therapeutic component may be subsequently released within an endocytic vesicle of the target cell. Nanoparticle-based drug delivery systems as described herein may provide improved efficacy and/or reduced toxicity.
    Creator
    Z. Basar Bilgicer, Tanyel Kiziltepe Bilgicer, Jonathan D. Ashley, Jared Stefanick, Nathan J. Alves, Michael W. Handlogten
    Publisher
    U.S. Patent and Trademark Office
    Language
    English
    Rights
    All rights reserved
    Resource Type
    Patent
1 entry found