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  Patent

  Multifunctional micellar nanoparticle-based drug and targeting agent system
  

  Inventor(s):

  Z. Basar Bilgicer, Tanyel Kiziltepe Bilgicer, Jonathan D. Ashley, Jared Stefanick, Nathan J. Alves, Michael W. Handlogten

  Patent Number:

  US 9872870 B2

  Description:

  Embodiments provide systems, methods, and compositions for nanoparticle-based drug delivery to target cells or tissues. A drug delivery system may include a nanoparticle with a targeting component and a therapeutic component. The nanoparticle may have a predetermined number or valence of targeting molecules for multivalent interaction with a target cell or tissue. Binding of the targeting molecules to the target cell may result in receptor-mediated uptake of the nanoparticle by the target cel…

  Date Issued:

  2018-01-23

  Record Visibility:

  Public

  Title

  Multifunctional micellar nanoparticle-based drug and targeting agent system

  Description

  Embodiments provide systems, methods, and compositions for nanoparticle-based drug delivery to target cells or tissues. A drug delivery system may include a nanoparticle with a targeting component and a therapeutic component. The nanoparticle may have a predetermined number or valence of targeting molecules for multivalent interaction with a target cell or tissue. Binding of the targeting molecules to the target cell may result in receptor-mediated uptake of the nanoparticle by the target cell. The therapeutic component may be subsequently released within an endocytic vesicle of the target cell. Nanoparticle-based drug delivery systems as described herein may provide improved efficacy and/or reduced toxicity.

  Creator

  Z. Basar Bilgicer, Tanyel Kiziltepe Bilgicer, Jonathan D. Ashley, Jared Stefanick, Nathan J. Alves, Michael W. Handlogten

  Publisher

  U.S. Patent and Trademark Office

  Language

  English

  Rights

  All rights reserved

  Resource Type

  Patent