Chemical and Biomolecular Engineering

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  • Inventor(s):
    Hsueh-Chia Chang, David T. Leighton
    Patent Number:
    US 6428754 B2
    Description:

    An exhaust gas treatment system and method for treating the exhaust gas of an internal combustion engine includes a catalytic converter and a catalytic preheater or igniter upstream of the catalytic converter. A bypass passage extends around the igniter such that during the ignition period about two-thirds of the exhaust gas is bypassed around the igniter and one-third passes through the igniter. The igniter raises the temperature of the exhaust gases passing therethrough to an adiabatic temp…

    Date Issued:
    2002-08-06
    Resource Type
    Patent
  • Inventor(s):
    Hsueh-Chia Chang, Shau-Chun Paul Wang, Dmitri Lastochkin, Leslie Yeo, Zachary Gagnon
    Patent Number:
    US 8267914 B1
    Description:

    The present invention provides an electrospray device using a high frequency alternating current (AC) above 10 kHz to generate fine micron sized drops. The apparatus generally functions by applying a high frequency alternating current electric field across one or more micro-needles and one or more conducting elements. The present invention may be used to generate aerosol drops for respiratory drug delivery or as a microencapsulation technique for the encapsulation of drugs, DNA, protein, oste…

    Date Issued:
    2012-09-18
    Resource Type
    Patent
  • Inventor(s):
    Shramik Sengupta, Hsueh-Chia Chang
    Patent Number:
    US 8635028 B2
    Description:

    An improved system and method is provided for detecting viable bacteria in a suspension sample. A sample of a suspension in which bacterial presence is suspected is collected from a source and a portion of the sample transferred to a microfluidic unit. A series of analysis signals at different frequencies are applied to the sample portion. An impedance is measured via a signal analyzer for the sample portion for each of the analysis signals to define an impedance data set. An initial bulk cap…

    Date Issued:
    2014-01-21
    Resource Type
    Patent
  • Inventor(s):
    Hsueh-Chia Chang, Zilin Chen, Fu-Chih Hsu, David Battigelli
    Patent Number:
    US 7960180 B2
    Description:

    Methods and apparatus to capture and release microbe particles using amino-functionalized silica substrates are described. An example apparatus adapted to capture a microbe particle includes a silica substrate and a positively charged material to at least partially coat the silica substrate. The positive charged material includes an aminopropyl functional group.

    Date Issued:
    2011-06-14
    Resource Type
    Patent
  • Inventor(s):
    Zachary Gagnon, Hsueh-Chia Chang
    Patent Number:
    US 7744738 B2
    Description:

    The present invention provides a method and apparatus for use in rapid particle transportation, separation, focusing, characterization, and release. Dielectrophoresis and electro-osmotic driven fluid convection are used independently or in tandem as the driving forces for particle manipulation and on occasion characterization. Although dielectrophoresis has been acknowledged for decades as a powerful technique for particle manipulation and characterization, long processing times and measureme…

    Date Issued:
    2010-06-29
    Resource Type
    Patent
  • Inventor(s):
    Nishant Chetwani, Catherine Cassou, David Go, Hsueh-Chia Chang
    Patent Number:
    US 8716675 B2
    Description:

    An alternating current electrospray mass spectrometry device includes an electrospray device having at least one emitter providing a passageway for transmission of an analyte sample. At least one conductive element is in electrical communication with the at least one emitter. A power source generates an alternating current electric field to form a liquid cone at a tip of the emitter and ionizes the analyte sample present in the liquid cone. The frequency of the electric field entrains low mob…

    Date Issued:
    2014-05-06
    Resource Type
    Patent
  • Inventor(s):
    Hsueh-Chia Chang, Jason Gordon, Satyajyoti Senapati, Zachary Gagnon, Sagnik Basuray
    Patent Number:
    US 8771938 B2
    Description:

    Disclosed are example methods and devices for detecting one or more targets. An example method includes placing a sample including a first target with in a microfluidic device and hybridizing a plurality of copies of the first target with a plurality of nanostructures. The example method includes applying an electric current to the plurality of nanostructures and using an electric field created by the electric current to move the plurality of nanostructures. In addition, the plurality of nano…

    Date Issued:
    2014-07-08
    Resource Type
    Patent
  • Inventor(s):
    Hsueh-Chia Chang, Peter Mushenheim, Sagnik Basuray, Gilad Yossifon, Satyajyoti Senapati
    Patent Number:
    US 8969007 B2
    Description:

    A microchamber electrochemical cell and method of using the cell for performing quantitative analysis of various charged macromolecules is presented. The microchamber electrochemical cell includes a substrate, opposing electrodes and at least one nanoslot. The substrate is configured to define a pair of opposing fluid reservoirs. The pair of opposing electrodes are respectively positioned within the opposing fluid reservoirs. Each nanoslot is configured to fluidly connect the opposing fluid r…

    Date Issued:
    2015-03-03
    Resource Type
    Patent
  • Inventor(s):
    Hsueh-Chia Chang, Shoupeng Liu, Satyajyoti Senapati, Yunshan Wang, Yu Yan
    Patent Number:
    US 9856518 B2
    Description:

    A nanopipette biosensor capable of detecting a small concentration of target molecules within a sample solution using optical detection methods. The biosensor includes a nanopipette that connects a nanocolloid reservoir containing a nanocolloid solution and a sample reservoir containing a sample solution, where the nanopipette is tapered at the end connected to the sample reservoir. The nanocolloid solution includes nanoparticles functionalized with probes specific to miRNA of the target mole…

    Date Issued:
    2018-01-02
    Resource Type
    Patent