Chemical and Biomolecular Engineering

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  • Inventor(s):
    Z. Basar Bilgicer, Tanyel Kiziltepe Bilgicer, Nathan J. Alves, Jonathan D. Ashley, Michael W. Handlogten
    Patent Number:
    US 9598460 B2
    Description:

    Embodiments herein provide methods of purifying monoclonal and polyclonal antibodies (e.g., immunoglobulins) from biological fluids, such as cell lysates, cell supernatant and ascites fluids, using small molecule affinity chromatography. Various embodiments disclose a class of small molecules that selectively bind a nucleotide binding site that is inherent to all immunoglobulins, and in various embodiments, methods are disclosed that use one of these small molecules as a capture molecule in s…

    Date Issued:
    2017-03-21
    Record Visibility:
    Public
    Resource Type
    Patent
  • Inventor(s):
    Z. Basar Bilgicer, Tanyel Kiziltepe Bilgicer, Jonathan D. Ashley, Jared Stefanick, Nathan J. Alves, Michael W. Handlogten
    Patent Number:
    US 9872870 B2
    Description:

    Embodiments provide systems, methods, and compositions for nanoparticle-based drug delivery to target cells or tissues. A drug delivery system may include a nanoparticle with a targeting component and a therapeutic component. The nanoparticle may have a predetermined number or valence of targeting molecules for multivalent interaction with a target cell or tissue. Binding of the targeting molecules to the target cell may result in receptor-mediated uptake of the nanoparticle by the target cel…

    Date Issued:
    2018-01-23
    Record Visibility:
    Public
    Resource Type
    Patent