Chemical and Biomolecular Engineering

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  • Inventor(s):
    Manuel Koucouthakis, Douglas J. Steinke, Alexander Mukasyan, Jeremiah D. E. White
    Patent Number:
    US 9321692 B2
    Description:

    Production of pore-free carbon/carbon-silicon carbide composite materials with mechanical properties making them suitable for use in such applications as the production of aircraft landing system brake components including brake discs. The method includes: providing a porous carbon-carbon composite preform; surrounding the porous carbon-carbon composite preform with silicon powder to form an intermediate construct; applying a uniaxial load to the construct; applying direct electrical current …

    Date Issued:
    2016-04-26
    Record Visibility:
    Public
    Resource Type
    Patent
  • Inventor(s):
    Hsueh-Chia Chang, Jason Gordon, Satyajyoti Senapati, Zachary Gagnon, Sagnik Basuray
    Patent Number:
    US 8771938 B2
    Description:

    Disclosed are example methods and devices for detecting one or more targets. An example method includes placing a sample including a first target with in a microfluidic device and hybridizing a plurality of copies of the first target with a plurality of nanostructures. The example method includes applying an electric current to the plurality of nanostructures and using an electric field created by the electric current to move the plurality of nanostructures. In addition, the plurality of nano…

    Date Issued:
    2014-07-08
    Record Visibility:
    Public
    Resource Type
    Patent
  • Inventor(s):
    Nishant Chetwani, Catherine Cassou, David Go, Hsueh-Chia Chang
    Patent Number:
    US 8716675 B2
    Description:

    An alternating current electrospray mass spectrometry device includes an electrospray device having at least one emitter providing a passageway for transmission of an analyte sample. At least one conductive element is in electrical communication with the at least one emitter. A power source generates an alternating current electric field to form a liquid cone at a tip of the emitter and ionizes the analyte sample present in the liquid cone. The frequency of the electric field entrains low mob…

    Date Issued:
    2014-05-06
    Record Visibility:
    Public
    Resource Type
    Patent
  • Inventor(s):
    Alexander Mukasyan, Khachatur Manukyan
    Patent Number:
    US 9580323 B2
    Description:

    The invention provides methods for the combustion synthesis (CS) of graphene by a novel exothermic self-sustained reaction between a refractory ceramic compound and a carbon-containing polymer under an inert gas atmosphere. The synthesis of graphene was confirmed by both transmission electron microscopy and Raman spectroscopy. The graphene produced has very low (<1 wt. %) oxygen content. Fluorocarbon gases released due to decomposition of the carbon-containing polymer in the combustion wav…

    Date Issued:
    2017-02-28
    Record Visibility:
    Public
    Resource Type
    Patent
  • Inventor(s):
    Z. Basar Bilgicer, Tanyel Kiziltepe Bilgicer, Nathan J. Alves, Jonathan D. Ashley, Michael W. Handlogten
    Patent Number:
    US 9598460 B2
    Description:

    Embodiments herein provide methods of purifying monoclonal and polyclonal antibodies (e.g., immunoglobulins) from biological fluids, such as cell lysates, cell supernatant and ascites fluids, using small molecule affinity chromatography. Various embodiments disclose a class of small molecules that selectively bind a nucleotide binding site that is inherent to all immunoglobulins, and in various embodiments, methods are disclosed that use one of these small molecules as a capture molecule in s…

    Date Issued:
    2017-03-21
    Record Visibility:
    Public
    Resource Type
    Patent
  • Inventor(s):
    Siyuan Zhang, Jeremiah Zartman, David Hoelzle, Cody Narciso
    Patent Number:
    US 9975121 B2
    Description:

    A microfluidic device for evaluating a tissue sample can include a tissue chamber, a liquid inlet channel, a liquid outlet channel, and at least one of components (1)-(3). The tissue chamber can be defined by a plurality of walls, at least one of which is transparent. The liquid inlet and outlet channels can be in fluid communication with the tissue chamber. Components (1)-(3) can include: (1) a deformable membrane disposed within the tissue chamber and being configured to oscillate, upon app…

    Date Issued:
    2018-05-22
    Record Visibility:
    Public
    Resource Type
    Patent
  • Inventor(s):
    Z. Basar Bilgicer, Tanyel Kiziltepe Bilgicer, Jonathan D. Ashley, Jared Stefanick, Nathan J. Alves, Michael W. Handlogten
    Patent Number:
    US 9872870 B2
    Description:

    Embodiments provide systems, methods, and compositions for nanoparticle-based drug delivery to target cells or tissues. A drug delivery system may include a nanoparticle with a targeting component and a therapeutic component. The nanoparticle may have a predetermined number or valence of targeting molecules for multivalent interaction with a target cell or tissue. Binding of the targeting molecules to the target cell may result in receptor-mediated uptake of the nanoparticle by the target cel…

    Date Issued:
    2018-01-23
    Record Visibility:
    Public
    Resource Type
    Patent
  • Inventor(s):
    Hsueh-Chia Chang, Shoupeng Liu, Satyajyoti Senapati, Yunshan Wang, Yu Yan
    Patent Number:
    US 9856518 B2
    Description:

    A nanopipette biosensor capable of detecting a small concentration of target molecules within a sample solution using optical detection methods. The biosensor includes a nanopipette that connects a nanocolloid reservoir containing a nanocolloid solution and a sample reservoir containing a sample solution, where the nanopipette is tapered at the end connected to the sample reservoir. The nanocolloid solution includes nanoparticles functionalized with probes specific to miRNA of the target mole…

    Date Issued:
    2018-01-02
    Record Visibility:
    Public
    Resource Type
    Patent
  • Inventor(s):
    Marvin J. Miller, Serena Carosso
    Patent Number:
    US 9862680 B2
    Description:

    The invention provides monobactams that can be used as antibacterial agents or intermediates for the preparation of other useful compounds such as antibacterial agents.

    Date Issued:
    2018-01-09
    Record Visibility:
    Public
    Resource Type
    Patent
  • Inventor(s):
    Allen H. Simpson, Mark L. La Forest, Alexander Mukasyan
    Patent Number:
    US 8574470 B2
    Description:

    Method of joining a carbon-carbon composite piece 30 together with a metal insert 20, e.g. in the manufacture of aircraft brake discs 10. The method includes the steps of: providing a carbon-carbon composite piece 30 and a metal insert 20, wherein the metal insert 20 has a surface that is complementary to a surface of said carbon-carbon composite piece 30; providing a layer of a mixture of titanium powder and carbon powder on the first complementary mating surface; arranging the powder layer …

    Date Issued:
    2013-11-05
    Record Visibility:
    Public
    Resource Type
    Patent
  • Inventor(s):
    Shramik Sengupta, Hsueh-Chia Chang
    Patent Number:
    US 8635028 B2
    Description:

    An improved system and method is provided for detecting viable bacteria in a suspension sample. A sample of a suspension in which bacterial presence is suspected is collected from a source and a portion of the sample transferred to a microfluidic unit. A series of analysis signals at different frequencies are applied to the sample portion. An impedance is measured via a signal analyzer for the sample portion for each of the analysis signals to define an impedance data set. An initial bulk cap…

    Date Issued:
    2014-01-21
    Record Visibility:
    Public
    Resource Type
    Patent
  • Inventor(s):
    Jason C. Hicks, Gregory T. Neumann
    Patent Number:
    US 8969599 B2
    Description:

    The invention provides a catalyst system for catalytic fast pyrolysis comprising a cerium-incorporated HZSM-5 zeolite (Catalyst 1), and methods of making and using the same. The invention also provides a process for reducing coke formation during catalytic fast pyrolysis of biomass using HZSM-5, wherein the process can include incorporating cerium into the HZSM-5 zeolite to produce Catalyst 1 prior to the catalytic fast pyrolysis.

    Date Issued:
    2015-03-03
    Record Visibility:
    Public
    Resource Type
    Patent