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  • Author(s):
    Yide Zhang
    Abstract:

    Multiphoton microscopy combined with fluorescence lifetime imaging microscopy (MPM-FLIM) is a technique that allows for imaging the lifetime of fluorescence created by two-photon excitation. It not only possesses the advantages of MPM such as large imaging depth, but also the strengths of FLIM including the ability to discriminate different fluorophores with similar emission spectra. In FLIM, the frequency-domain (FD) method, which relies on periodic intensity-modulated excitation light and i…

    Date Created:
    2015-10-22
    Record Visibility:
    Public
    Resource Type
    Presentation
  • Author(s):
    Yide Zhang
    Abstract:

    In cancer and all biomedical researches, we always need a microscope with better imaging precision, speed, functionality, and depth, so that the diagnostics and treatments of cancer and other diseases can be accurate, fast, and noninvasive. However, conventional fluorescence microscopes cannot satisfy these needs due to physical limits on resolution, speed, information, and depth. In this work, we aim to overcome these limits using novel super-resolution microscopy and high-speed quantitative…

    Date Created:
    2018-04-09
    Record Visibility:
    Public
    Resource Type
    Presentation
  • Author(s):
    Yide Zhang
    Abstract:

    Multiphoton microscopy (MPM) is a widely used in vivo imaging technique in biological and medical applications. In the case of two-photon excitation fluorescence, two lower-energy photons excite a fluorophore which in turn emits a single higher-energy photon, whose rate depends quadratically on the excitation intensity, thus enabling higher resolution with narrower point spread function (PSF) than conventional one-photon fluorescence microscopy. Fluorescence lifetime imaging microscopy (FLIM)…

    Date Created:
    2016-04-04
    Record Visibility:
    Public
    Resource Type
    Presentation
  • Author(s):
    Yide Zhang
    Abstract:

    To fundamentally understand biological and medical phenomena such as aging and diseases, we need the information of the microenvironment surrounding living cells. We propose the multiphoton fluorescence lifetime imaging microscopy (MPM-FLIM) platform with super-sensitivity and super-resolution capabilities to quantitatively obtain this information at the intracellular level. First, we present a simple MPM oxygen imaging probe compatible with aqueous biological media based on water-soluble rut…

    Date Created:
    2017-03-30
    Record Visibility:
    Public
    Resource Type
    Presentation
  • Author(s):
    Yide Zhang
    Abstract:

    Super-resolution fluorescence microscopy is an important tool in biomedical research for its ability to discern features smaller than the diffraction limit, but its universal application is not feasible due to its difficult implementation and high cost. In this research, we propose and demonstrate a new kind of super-resolution fluorescence microscopy that can be easily implemented and requires neither additional hardware nor complex post-processing. The microscopy is based on the principle o…

    Date Created:
    2017-10-19
    Record Visibility:
    Public
    Resource Type
    Presentation
  • Inventor(s):
    Ken D. Sauer, Charles A. Bouman, Jean-Baptiste Thibault, Jiang Hsieh
    Patent Number:
    US 6907102 B2
    Description:

    A multi-slice computed tomography imaging system is provided including a source that generates an x-ray beam and a detector array that receives the x-ray beam and generates projection data. A translatable table has an object thereon and is operable to translate in relation to the source and the detector array. The source and the detector array rotate about the translatable table to helically scan the object. An image reconstructor is electrically coupled to the detector array and reconstructs…

    Date Issued:
    2005-06-14
    Record Visibility:
    Public
    Resource Type
    Patent
  • Inventor(s):
    Peter M. Kogge, Jay B. Brockman, David Tennyson Harper, Burton Smith, Charles David Callahan
    Patent Number:
    US 7584332 B2
    Description:

    Embodiments of the present invention provide a class of computer architectures generally referred to as lightweight multi-threaded architectures (LIMA). Other embodiments may be described and claimed.

    Date Issued:
    2009-09-01
    Record Visibility:
    Public
    Resource Type
    Patent
  • Inventor(s):
    Ken D. Sauer, Charles A. Bouman, Jiang Hsieh, Jean-Baptiste Thibault
    Patent Number:
    US 7676074 B2
    Description:

    A method for filtering a measurement of density of an object is described. The method includes filtering the measurement of the density and preserving a local average of the measurement and additional measurements when performing the filtering.

    Date Issued:
    2010-03-09
    Record Visibility:
    Public
    Resource Type
    Patent
  • Inventor(s):
    Douglas C. Hall, Mingjun Huang
    Patent Number:
    US 7655489 B2
    Description:

    Disclosed is a method of doping an oxide. The example method includes forming at least one of an AlGaAs oxide or an InAlP oxide on a GaAs substrate, and incorporating Erbium into the at least one AlGaAs oxide or InAlP oxide via ion implantation to form an Erbium-doped oxide layer. The example method also includes annealing the substrate and the at least one AlGaAs oxide or InAlP oxide.

    Date Issued:
    2010-02-02
    Record Visibility:
    Public
    Resource Type
    Patent
  • Inventor(s):
    Peter M. Kogge
    Patent Number:
    US 7185150 B2
    Description:

    A computer system comprising: a plurality of memories each containing one or more locations; and a first threadlet for causing a first program to run in the computer system when at least one first memory location of the plurality of memory locations is local to the threadlet. Also provided is a method allowing such a threadlet to move itself to memories that include some specified second memory location.

    Date Issued:
    2007-02-27
    Record Visibility:
    Public
    Resource Type
    Patent
  • Inventor(s):
    Jiang Hsieh, Charles A. Bouman, Ken D. Sauer, Jean-Baptiste Thibault
    Patent Number:
    US 7440602 B2
    Description:

    A method for improving images of an imaging system including a plurality of detector cells includes assigning a quality factor for each detector cell.

    Date Issued:
    2008-10-21
    Record Visibility:
    Public
    Resource Type
    Patent
  • Inventor(s):
    Gary H. Bernstein, Patrick Fay, Wolfgang Porod, Qing Liu
    Patent Number:
    US 7612443 B2
    Description:

    The present invention provides a quilt packaging system for microchip, a method for making such a quilt packaging system, microchips that may be used in a such a quilt packaging system, and methods for making such microchips.

    Date Issued:
    2009-11-03
    Record Visibility:
    Public
    Resource Type
    Patent