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1
Article

Skeletal cell YAP and TAZ combinatorially promote bone development

Author(s):

Devon E. Mason, James H. Dawahare, Daniel J. Horan, Genevieve D. Vigil, Scott S. Howard,, Alexander G. Robling, , Teresita M. Bellido, Joel D. Boerckel

Abstract:

The functions of the paralogous transcriptional coactivators Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ) in bone are controversial. Each has been observed to promote or inhibit osteogenesis in vitro, with reports of both equivalent and divergent functions. Their combinatorial roles in bone physiology are unknown. We report that combinatorial YAP/TAZ deletion from skeletal lineage cells, using Osterix-Cre, caused an osteogenesis imperfecta-like phe…

Date Published:

2018-05