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  Article

  Human iPSC-derived myocardium-on-chip with capillary-like flow for personalized medicine
  

  Author(s):

  Bradley Ellis, Aylin Acun, U. Isik Can, Pinar Zorlutuna

  Abstract:

  The heart wall tissue, or the myocardium, is one of the main targets in cardiovascular disease prevention and treatment. Animal models have not been sufficient in mimicking the human myocardium as evident by the very low clinical translation rates of cardiovascular drugs. Additionally, current in vitro models of the human myocardium possess several shortcomings such as lack of physiologically relevant co-culture of myocardial cells, lack of a 3D biomimetic environment, and the use of non-huma…

  Date Published:

  2017-03