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  • Author(s):
    Yide Zhang, Prakash Nallathamby, Genevieve D. Vigil, Aamir A. Khan, Devon E. Mason, Joel D. Boerckel, Ryan K. Roeder, Scott S. Howard
    Abstract:

    Super-resolution fluorescence microscopy is an important tool in biomedical research for its ability to discern features smaller than the diffraction limit. However, due to its difficult implementation and high cost, the super-resolution microscopy is not feasible in many applications. In this paper, we propose and demonstrate a saturation-based super-resolution fluorescence microscopy technique that can be easily implemented and requires neither additional hardware nor complex post-processin…

    Date Published:
    2018-04
  • Author(s):
    Christopher D. Kagelman, Devon E. Mason, James H. Dawahare, Genevieve D. Vigil, Scott S. Howard, Teresita M. Bellido, Alexander G. Robling, Joel Boerckel
    Abstract:

    The functions of the transcriptional co-activators YAP and TAZ in bone are controversial. Each has been observed to either promote or inhibit osteogenesis in vitro, while their roles in bone development are unknown. Here we report that combinatorial YAP/TAZ deletion from skeletal cells in mice caused osteogenesis imperfecta with severity dependent on targeted cell lineage and allele dosage. Osteocyte-conditional deletion impaired bone accrual and matrix collagen, while allele dosage-dependent…

    Date Published:
    2017-05