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  • Author(s):
    Glen Niebur
    Abstract:

    Most patients who succumb to cancer have metastases to bone that contribute to their death. Cancer cells that metastasize to bone are regularly subjected to mechanical stimuli that may affect their proliferation, growth and protein expression. Understanding why some cancer cells thrive in this environment could provide insight into new approaches to prevent or treat metastasis to bone. We used 4T1 cells as a model of breast cancer cells, and implanted them in gelatin hydrogels with moduli of …

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  • Author(s):
    Glen Niebur
    Abstract:

    Most patients who succumb to cancer have metastases to bone that contribute to their death. Cancer cells that metastasize to bone are regularly subjected to mechanical stimuli that may affect their proliferation, growth and protein expression. Understanding why some cancer cells thrive in this environment could provide insight into new approaches to prevent or treat metastasis to bone. We used 4T1 cells as a model of breast cancer cells, and implanted them in gelatin hydrogels with moduli of …

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  • Creator(s):
    Glen L. Niebur, Kimberly J. Curtis
    Description:

    Segmented computed tomography images of bone samples in Scanco AIM format (read with ImageJ): xxxx_seg.aim VTK format images of CFD results showing shear stress in the marrow (variable s0) (read with Python or other VTK compatible software): xxxxx.vtk Excel spreadsheet with gene expression data: xxx.xlsx

    Date Created:
    2019-04-24
    Record Visibility:
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  • Creator(s):
    David H Richter, Anne E Dempsey
    Description:

    Data for the reproduction of figures found in the paper Turbulent transport of spray droplets in the vicinity of moving surface waves written by David Richter et al.

    Included in this data set is: Spray Droplet Concentration, normalized velocity, and surf. Joint probability distributions of the droplet ejection location with (a) the droplet death location, (b) the maximum height reached by the droplet during its lifetime, and © the droplet lifetime for Cases d10 and d100.

    Date Created:
    2019-03-29
    Record Visibility:
    Public
  • Author(s):
    Jeremy Fein, Clayton Johnson, Joshua Shrout
    Abstract:

    Understanding metal sorption to bacteria is important for developing bioremediation strategies, for determining the fate of contaminants in ground water systems, and for defining controls on microbial metabolic processes in the environment. X-ray absorption spectroscopy (XAS) has been the only technique available for quantifying and mapping metal sorption to bacteria on an individual cell scale, but the XAS approach is time consuming and expensive, and quantitative mapping of the distribution…

    Date Published:
    2018-04
    Record Visibility:
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  • Author(s):
    Jakub Plášil, Anthony R. Kampf, Peter C. Burns
    Abstract:

    Redcanyonite (IMA2016-082), (NH4)2Mn(UO2)4O4(SO4)24, occursunderground in the Blue Lizard mine, Red Canyon, White Canyon district,San Juan County, Utah, USA. It occurs with natrozippeite, brochantite, devilline, posnjakite, johannite, gypsum, bobcookite, pickingerite, pentahydrite, and the NH4-analog of zippeite, ammoniozippeite. Redcanyonite occurs as radial aggregates of red-orange needles and blades individually reaching up to 0.2 mm in length, with aggregates measuring up to 1 mm i…

    Date Published:
    2018-05
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  • Author(s):
    Bradley Ellis, Aylin Acun, U. Isik Can, Pinar Zorlutuna
    Abstract:

    The heart wall tissue, or the myocardium, is one of the main targets in cardiovascular disease prevention and treatment. Animal models have not been sufficient in mimicking the human myocardium as evident by the very low clinical translation rates of cardiovascular drugs. Additionally, current in vitro models of the human myocardium possess several shortcomings such as lack of physiologically relevant co-culture of myocardial cells, lack of a 3D biomimetic environment, and the use of non-huma…

    Date Published:
    2017-03
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  • Author(s):
    Genevieve D. Vigil, Lina Cao, Aamir A. Khan, David Benirschke, Tahsin Ahmed, Patrick Fay, Scott S. Howard
    Abstract:

    Fluorophore saturation is the key factor limiting the speed and excitation range of fluorescence lifetime imaging microscopy (FLIM). For example, fluorophore saturation causes incorrect lifetime measurements when using conventional frequency-domain FLIM at high excitation powers. In this Letter, we present an analytical theoretical description of this error and present a method for compensating for this error in order to extract correct lifetime measurements in the limit of fluorophore satura…

    Date Published:
    2016-12
    Record Visibility:
    Public
  • Author(s):
    Shirou Lou, Jarrod Schiffbauer, Tengfei Lou
    Abstract:

    In this work, the droplet size in a water-in-oil emulsion obtained by supersaturation is studied. The emulsion is obtained by cooling down a saturated water/oil solution by a certain temperature difference. The effects of the cooling rate and temperature difference on the produced droplet size are experimentally investigated. The average size of water droplets in the emulsion is found to be proportional to the square root of the cooling rate. By analyzing the time scales of three different st…

    Date Published:
    2017-10
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  • Author(s):
    Yide Zhang, Prakash Nallathamby, Genevieve D. Vigil, Aamir A. Khan, Devon E. Mason, Joel D. Boerckel, Ryan K. Roeder, Scott S. Howard
    Abstract:

    Super-resolution fluorescence microscopy is an important tool in biomedical research for its ability to discern features smaller than the diffraction limit. However, due to its difficult implementation and high cost, the super-resolution microscopy is not feasible in many applications. In this paper, we propose and demonstrate a saturation-based super-resolution fluorescence microscopy technique that can be easily implemented and requires neither additional hardware nor complex post-processin…

    Date Published:
    2018-04
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  • Author(s):
    Pavel A. Brodkiy, Qinfeng Wu, Francisco J. Huizar, Dharsan K. Soundarrajan, Cody Narciso, Megan evis, Ninfamaria Arredondo-Walsh, Jianxu Chen, Peixian Liang, Danny Z. Chen, Jeremiah James Zartman
    Abstract:

    Organ development is driven by a set of patterned inductive signals. However, how these signals are integrated to coordinate tissue patterning is still poorly understood. Calcium ions (Ca2+) are critical signaling components involved in signal integration and are regulated by a core Ca2+ signaling toolkit. Ca2+ signaling encodes a significant fraction of information in cells through both amplitude and frequency-dependent regulation of transcription factors and key regulatory enzymes. A range …

    Date Published:
    2017-09
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  • Author(s):
    Cody E. Narcisco, Nicholas M. Contento, Thomas J. Storey, David J. Hoelzle, Jeremiah J. Zartman
    Abstract:

    Mechanical forces are critical but poorly understood inputs for organogenesis and wound healing. Calcium ions (Ca2+) are critical second messengers in cells for integrating environmental and mechanical cues, but the regulation of Ca2+ signaling is poorly understood in developing epithelial tissues. Here we report a chip-based regulated environment for microorgans that enables systematic investigations of the crosstalk between an organ’s mechanical stress environment and biochemical signaling …

    Date Published:
    2017-07
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