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  • Author(s):
    Qinfeng Wu, Pavel Aleksandrovich Brodkiy, Francisco Javier Huizar, Jamison John Jangula, Cody Narciso, Megan Kathleen Levis, Teresa Brito-Robinson, Jeremiah J. Zartman
    Abstract:

    Recently, organ-scale intercellular Ca2+ transients (ICTs) were reported in the Drosophila wing disc. However, the functional in vivo significance of ICTs remains largely unknown. Here we demonstrate the in vivo relevance of intercellular Ca2+ signaling and its impact on wing development. We report that Ca2+ signaling in vivo decreases as wing discs mature. Ca2+ signaling ex vivo responds to fly extract in a dose-dependent manner. This suggests ICTs occur in vivo due to chemical stimulus that…

    Date Published:
    2017-09
  • Author(s):
    M. McFadden, J. Loconsole, A. J. Schockling, R. Nerenberg, J. P. .Pavassich
    Abstract:

    Peracetic acid (PAA) is an alternative disinfectant that may be effective for combined sewer overflow (CSO) disinfection, but little is known about the effect of particle size on PAA disinfection efficiency. In this work, PAA and hypochlorite were compared as disinfectants, with a focus on the effect of wastewater particles. Inactivation experiments were conducted on suspended cultures of Escherichia coli and wastewater suspended solids. Tested size fractions included particle diameters < …

    Date Published:
    2017-12
  • Author(s):
    Devon E. Mason, James H. Dawahare, Daniel J. Horan, Genevieve D. Vigil, Scott S. Howard,, Alexander G. Robling, , Teresita M. Bellido, Joel D. Boerckel
    Abstract:

    The functions of the paralogous transcriptional coactivators Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ) in bone are controversial. Each has been observed to promote or inhibit osteogenesis in vitro, with reports of both equivalent and divergent functions. Their combinatorial roles in bone physiology are unknown. We report that combinatorial YAP/TAZ deletion from skeletal lineage cells, using Osterix-Cre, caused an osteogenesis imperfecta-like phe…

    Date Published:
    2018-05
  • Author(s):
    Christopher D. Kagelman, Devon E. Mason, James H. Dawahare, Genevieve D. Vigil, Scott S. Howard, Teresita M. Bellido, Alexander G. Robling, Joel Boerckel
    Abstract:

    The functions of the transcriptional co-activators YAP and TAZ in bone are controversial. Each has been observed to either promote or inhibit osteogenesis in vitro, while their roles in bone development are unknown. Here we report that combinatorial YAP/TAZ deletion from skeletal cells in mice caused osteogenesis imperfecta with severity dependent on targeted cell lineage and allele dosage. Osteocyte-conditional deletion impaired bone accrual and matrix collagen, while allele dosage-dependent…

    Date Published:
    2017-05
  • Author(s):
    Angela Chesler
    Abstract:

    As climate changes, coastal homeowners are potentially crucial actors in reducing the risks to property and human life from rising seas and increased hurricane activity. Absent strict, enforceable regulations mandating retrofitting of existing homes or major changes in homeowner insurance requirements, coastal resilience in a changing climate will largely reflect private, voluntary decisions of millions of individuals. However, research is scarce on the current risk level of U.S. coastal home…

    Date Created:
    2018-08-15
    Resource Type
    Document
  • Author(s):
    Angela Chesler
    Abstract:

    As climate changes, coastal homeowners are potentially crucial actors in reducing the risks to property and human life from rising seas and increased hurricane activity. Absent strict, enforceable regulations mandating retrofitting of existing homes or major changes in homeowner insurance requirements, coastal resilience in a changing climate will largely reflect private, voluntary decisions of millions of individuals. However, research is scarce on the current risk level of U.S. coastal home…

    Date Created:
    2018-08-15
    Resource Type
    Document
  • Author(s):
    Tracy Kijewski-Correa, Debra Javeline
    Abstract:

    As climate changes, coastal homeowners are potentially crucial actors in reducing the risks to property and human life from rising seas and increased hurricane activity. Absent strict, enforceable regulations mandating retrofitting of existing homes or major changes in homeowner insurance requirements, coastal resilience in a changing climate will largely reflect private, voluntary decisions of millions of individuals. However, research is scarce on the current risk level of U.S. coastal home…

    Date Created:
    2018-05-22
    Resource Type
    Document
  • Author(s):
    Debra Javeline, Tracy Kijewski-Correa
    Abstract:

    As climate changes, coastal homeowners are potentially crucial actors in reducing the risks to property and human life from rising seas and increased hurricane activity. Absent strict, enforceable regulations mandating retrofitting of existing homes or major changes in homeowner insurance requirements, coastal resilience in a changing climate will largely reflect private, voluntary decisions of millions of individuals. However, research is scarce on the current risk level of U.S. coastal home…

    Date Created:
    2017-06-13
    Resource Type
    Document
  • Author(s):
    Douglas Thain, Peter Ivie, Haiyan Meng
    Abstract:

    An increasing amount of scientific work is performed in silico, such that the entire process of investigation, from experiment to publication, is performed by computer. Unfortunately, this has made the problem of scientific reproducibility even harder, due to the complexity and imprecision of specifying and recreating the computing environments needed to run a given piece of software. Here, we consider from a high level what techniques and technologies must be put in place to allow for the ac…

  • Author(s):
    Peter Ivie, Anna Woodard, Matthias Wolf, Douglas Thain, Kevin Lannon, Michael Hildreth, Rob Gardner
    Abstract:

    The DASPOS project is an NSF-funded collaborative research project designed to explore the technical means of preserving the data and software components necessary to reproduce and build upon published scientific results. This technical report series consists of short reports that outline background, case studies, and technical results related to data preservation, with a focus on high energy physics.