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  • Author(s):
    Cody E. Narcisco, Nicholas M. Contento, Thomas J. Storey, David J. Hoelzle, Jeremiah J. Zartman
    Abstract:

    Mechanical forces are critical but poorly understood inputs for organogenesis and wound healing. Calcium ions (Ca2+) are critical second messengers in cells for integrating environmental and mechanical cues, but the regulation of Ca2+ signaling is poorly understood in developing epithelial tissues. Here we report a chip-based regulated environment for microorgans that enables systematic investigations of the crosstalk between an organ’s mechanical stress environment and biochemical signaling …

    Date Published:
    2017-07
    Record Visibility:
    Public
  • Author(s):
    Qinfeng Wu, Pavel Aleksandrovich Brodkiy, Francisco Javier Huizar, Jamison John Jangula, Cody Narciso, Megan Kathleen Levis, Teresa Brito-Robinson, Jeremiah J. Zartman
    Abstract:

    Recently, organ-scale intercellular Ca2+ transients (ICTs) were reported in the Drosophila wing disc. However, the functional in vivo significance of ICTs remains largely unknown. Here we demonstrate the in vivo relevance of intercellular Ca2+ signaling and its impact on wing development. We report that Ca2+ signaling in vivo decreases as wing discs mature. Ca2+ signaling ex vivo responds to fly extract in a dose-dependent manner. This suggests ICTs occur in vivo due to chemical stimulus that…

    Date Published:
    2017-09
    Record Visibility:
    Public