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  • Author(s):
    Ankit Agrawal, Seyedehzahra Khoshmanesh, Michael Vierhauser, Mona Rahimi, Jane Cleland-Huang, Robyn Lutz
    Abstract:

    Safety Assurance Cases (SACs) are increasingly used to guide and evaluate the safety of software-intensive systems. They are used to construct a hierarchically organized set of claims, arguments, and evidence in order to provide a structured argument that a system is safe for use. However, as the system evolves and grows in size, a SAC can be difficult to maintain. In this paper we utilize design science to develop a novel solution for identifying areas of a SAC that are affected by changes t…

    Date Published:
    2019-05
  • Author(s):
    Rick Rabiser, Klaus Schmid, Holger Eichelberger, Michael Vierhauser, Sam Guinea, Paul Gruenbacher
    Abstract:

    [Context] Complex and heterogeneous software systems need to be monitored as their full behavior often only emerges at runtime, e.g., when interacting with other systems or the environment. Software monitoring approaches observe and check properties or quality attributes of software systems during operation. Such approaches have been developed in diverse communities for various kinds of systems and purposes. For instance, requirements monitoring aims to check at runtime whether a software…

  • Author(s):
    Michael Vierhauser, Sean Beyley, Jane Wyngaard, Wandi Xiong, Joshua Huseman, Robyn Lutz, Jane Cleland-Huang
    Abstract:

    The growing adoption of unmanned aerial vehicles (UAV) for tasks such as eCommerce, aerial surveillance, and environmental monitoring introduces the need for new safety mechanisms in an increasingly cluttered airspace. In our work we thus emphasize safety issues that emerge at the intersection of infrastructures responsible for controlling the airspace, and the diverse UAVs operating in their space. We build on safety assurance cases (SAC)- a state-of-the-art solution for reasoning about safe…

  • Author(s):
    Norbert Seyff, Michael Vierhauser, Michael Schneider, Jane Cleland-Huang
    Abstract:

    [Context and motivation] With the rise of cyber-physical systems (CPS), smart ecosystems, and the Internet of Things (IoT), software-intensive systems have become pervasive in everyone’s daily life. The shift from software systems to ubiquitous adaptive software-intensive systems not only affects the way we use software but further has an impact on the way these systems are designed and developed. Gathering requirements for such systems can benefit from elicitation processes that are conducte…

  • Author(s):
    Jane Cleland-Huang, Michael Vierhauser
    Abstract:

    Traditionally, safety-critical projects have been developed using the waterfall process. However, this makes it costly and challenging to incrementally introduce new features and to certify the modified product for use. As a result, there has been increasing interest in adopting agile development paradigms within the safety-critical domain. This in turn introduces numerous challenges. In this paper we address the specific problems of discovering, analyzing, specifying, and managing safety req…

    Date Published:
    2018-08
  • Author(s):
    Yide Zhang
    Abstract:

    Multiphoton microscopy combined with fluorescence lifetime imaging microscopy (MPM-FLIM) is a technique that allows for imaging the lifetime of fluorescence created by two-photon excitation. It not only possesses the advantages of MPM such as large imaging depth, but also the strengths of FLIM including the ability to discriminate different fluorophores with similar emission spectra. In FLIM, the frequency-domain (FD) method, which relies on periodic intensity-modulated excitation light and i…

    Date Created:
    2015-10-22
    Resource Type
    Presentation
  • Author(s):
    Yide Zhang
    Abstract:

    In cancer and all biomedical researches, we always need a microscope with better imaging precision, speed, functionality, and depth, so that the diagnostics and treatments of cancer and other diseases can be accurate, fast, and noninvasive. However, conventional fluorescence microscopes cannot satisfy these needs due to physical limits on resolution, speed, information, and depth. In this work, we aim to overcome these limits using novel super-resolution microscopy and high-speed quantitative…

    Date Created:
    2018-04-09
    Resource Type
    Presentation
  • Author(s):
    Yide Zhang
    Abstract:

    Multiphoton microscopy (MPM) is a widely used in vivo imaging technique in biological and medical applications. In the case of two-photon excitation fluorescence, two lower-energy photons excite a fluorophore which in turn emits a single higher-energy photon, whose rate depends quadratically on the excitation intensity, thus enabling higher resolution with narrower point spread function (PSF) than conventional one-photon fluorescence microscopy. Fluorescence lifetime imaging microscopy (FLIM)…

    Date Created:
    2016-04-04
    Resource Type
    Presentation
  • Author(s):
    Yide Zhang
    Abstract:

    To fundamentally understand biological and medical phenomena such as aging and diseases, we need the information of the microenvironment surrounding living cells. We propose the multiphoton fluorescence lifetime imaging microscopy (MPM-FLIM) platform with super-sensitivity and super-resolution capabilities to quantitatively obtain this information at the intracellular level. First, we present a simple MPM oxygen imaging probe compatible with aqueous biological media based on water-soluble rut…

    Date Created:
    2017-03-30
    Resource Type
    Presentation
  • Author(s):
    Yide Zhang
    Abstract:

    Super-resolution fluorescence microscopy is an important tool in biomedical research for its ability to discern features smaller than the diffraction limit, but its universal application is not feasible due to its difficult implementation and high cost. In this research, we propose and demonstrate a new kind of super-resolution fluorescence microscopy that can be easily implemented and requires neither additional hardware nor complex post-processing. The microscopy is based on the principle o…

    Date Created:
    2017-10-19
    Resource Type
    Presentation
  • Author(s):
    Michael Vierhauser, Jane Cleland-Huang, Rick Rabiser, Thomas Krismayer, Paul Grünbacher
    Abstract:

    Industrial software systems are often systems of systems~(SoS) whose full behavior only emerges during operation. They therefore require monitoring techniques to observe systems and detect deviations from their requirements. The focus of existing monitoring approaches, however, is mainly on detecting violations of expected behavior, while support for diagnosing violations is typically limited or even neglected. Diagnosis is particularly challenging in SoS due to their technological heterogene…

    Date Published:
    2018-08
  • Author(s):
    Kyle Sweeney, Douglas Thain
    Abstract:

    Scientists using workflows often have access to both High Performance Computing and High-Throughput Computing sites, but HPC sites’ architecture is less conducive to HTC paradigms. The choices of middleware and site can have drastic performance differences on different workflows. To explore these differences, we created tools to expand Makeflow and Work Queue’s capabilities. We then performed four speed of light tests, testing job dispatch rate, data delivery from the master to worker…