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  • Author(s):
    Yide Zhang
    Abstract:

    Multiphoton microscopy combined with fluorescence lifetime imaging microscopy (MPM-FLIM) is a technique that allows for imaging the lifetime of fluorescence created by two-photon excitation. It not only possesses the advantages of MPM such as large imaging depth, but also the strengths of FLIM including the ability to discriminate different fluorophores with similar emission spectra. In FLIM, the frequency-domain (FD) method, which relies on periodic intensity-modulated excitation light and i…

    Date Created:
    2015-10-22
    Resource Type
    Presentation
  • Author(s):
    Yide Zhang
    Abstract:

    In cancer and all biomedical researches, we always need a microscope with better imaging precision, speed, functionality, and depth, so that the diagnostics and treatments of cancer and other diseases can be accurate, fast, and noninvasive. However, conventional fluorescence microscopes cannot satisfy these needs due to physical limits on resolution, speed, information, and depth. In this work, we aim to overcome these limits using novel super-resolution microscopy and high-speed quantitative…

    Date Created:
    2018-04-09
    Resource Type
    Presentation
  • Author(s):
    Yide Zhang
    Abstract:

    Multiphoton microscopy (MPM) is a widely used in vivo imaging technique in biological and medical applications. In the case of two-photon excitation fluorescence, two lower-energy photons excite a fluorophore which in turn emits a single higher-energy photon, whose rate depends quadratically on the excitation intensity, thus enabling higher resolution with narrower point spread function (PSF) than conventional one-photon fluorescence microscopy. Fluorescence lifetime imaging microscopy (FLIM)…

    Date Created:
    2016-04-04
    Resource Type
    Presentation
  • Author(s):
    Yide Zhang
    Abstract:

    To fundamentally understand biological and medical phenomena such as aging and diseases, we need the information of the microenvironment surrounding living cells. We propose the multiphoton fluorescence lifetime imaging microscopy (MPM-FLIM) platform with super-sensitivity and super-resolution capabilities to quantitatively obtain this information at the intracellular level. First, we present a simple MPM oxygen imaging probe compatible with aqueous biological media based on water-soluble rut…

    Date Created:
    2017-03-30
    Resource Type
    Presentation
  • Author(s):
    Yide Zhang
    Abstract:

    Super-resolution fluorescence microscopy is an important tool in biomedical research for its ability to discern features smaller than the diffraction limit, but its universal application is not feasible due to its difficult implementation and high cost. In this research, we propose and demonstrate a new kind of super-resolution fluorescence microscopy that can be easily implemented and requires neither additional hardware nor complex post-processing. The microscopy is based on the principle o…

    Date Created:
    2017-10-19
    Resource Type
    Presentation
  • Author(s):
    Tianze Peng, David Richter
    Abstract:

    Sea-spray droplets ejected into the air-sea boundary layer take part in a series of complex transport processes. To model the air-sea exchange of heat under high-wind conditions, it is important yet challenging to understand influences of evaporative droplets in the atmospheric boundary layer. We implement a high-resolution Eulerian-Lagrangian algorithm with varied droplets laden in a turbulent open-channel flow to reveal the dynamic and thermodynamic characteristics of droplets. Our past num…

    Date Created:
    2017-12-14
    Resource Type
    Presentation
  • Inventor(s):
    Mark Muldoon, Joan F. Brennecke, Edward J. Maginn, Eric F. V. Scriven, Colin H. McAteer
    Patent Number:
    US 7687513 B2
    Description:

    Disclosed herein are aminopyridinium cations and compositions containing these cations. Piperidino pyridinium cations and compositions containing these cations are also described. Ionic compositions, particularly liquid ionic compositions that contain the aminopyridinium cation or piperidino pyridinium cation are also described. Methods of enhancing the thermal stability of a compound, particularly an ionic compound, using the aminopyridinium or piperidino pyridinium cations, are also present…

    Date Issued:
    2010-03-30
    Resource Type
    Patent
  • Inventor(s):
    Eric Matlis, Thomas C. Corke, Sivaram Gogineni
    Patent Number:
    US 7275013 B2
    Description:

    Methods and systems are described for a system for obtaining information regarding a flow. These methods and systems comprise a signal generator configured to generate an alternating current signal at a carrier frequency and a transformer arranged to receive the generated signal, wherein the transformer and carrier frequency are selected so that the generated signal resonates at the carrier frequency. The alternating signal is then used to cause plasma to form across a gap between two electro…

    Date Issued:
    2007-09-25
    Resource Type
    Patent
  • Inventor(s):
    Ken D. Sauer, Charles A. Bouman, Jean-Baptiste Thibault, Jiang Hsieh
    Patent Number:
    US 6907102 B2
    Description:

    A multi-slice computed tomography imaging system is provided including a source that generates an x-ray beam and a detector array that receives the x-ray beam and generates projection data. A translatable table has an object thereon and is operable to translate in relation to the source and the detector array. The source and the detector array rotate about the translatable table to helically scan the object. An image reconstructor is electrically coupled to the detector array and reconstructs…

    Date Issued:
    2005-06-14
    Resource Type
    Patent
  • Inventor(s):
    Mehul Patel, Thomas C. Corke
    Patent Number:
    US 7954768 B2
    Description:

    A method of controlling an aircraft, missile, munition or ground vehicle with plasma actuators, and more particularly of controlling fluid flow across their surfaces or other surfaces which would benefit from such a method, includes the design of an aerodynamic plasma actuator for the purpose of controlling airflow separation over a control surface of a aircraft, missile, or a ground vehicle, and a method of determining a modulation frequency for the plasma actuator for the purpose of fluid f…

    Date Issued:
    2011-06-07
    Resource Type
    Patent
  • Inventor(s):
    Peter M. Kogge, Jay B. Brockman, David Tennyson Harper, Burton Smith, Charles David Callahan
    Patent Number:
    US 7584332 B2
    Description:

    Embodiments of the present invention provide a class of computer architectures generally referred to as lightweight multi-threaded architectures (LIMA). Other embodiments may be described and claimed.

    Date Issued:
    2009-09-01
    Resource Type
    Patent
  • Inventor(s):
    Ken D. Sauer, Charles A. Bouman, Jiang Hsieh, Jean-Baptiste Thibault
    Patent Number:
    US 7676074 B2
    Description:

    A method for filtering a measurement of density of an object is described. The method includes filtering the measurement of the density and preserving a local average of the measurement and additional measurements when performing the filtering.

    Date Issued:
    2010-03-09
    Resource Type
    Patent