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  • Author(s):
    Shirou Lou, Jarrod Schiffbauer, Tengfei Lou
    Abstract:

    In this work, the droplet size in a water-in-oil emulsion obtained by supersaturation is studied. The emulsion is obtained by cooling down a saturated water/oil solution by a certain temperature difference. The effects of the cooling rate and temperature difference on the produced droplet size are experimentally investigated. The average size of water droplets in the emulsion is found to be proportional to the square root of the cooling rate. By analyzing the time scales of three different st…

    Date Published:
    2017-10
  • Author(s):
    Yide Zhang, Prakash Nallathamby, Genevieve D. Vigil, Aamir A. Khan, Devon E. Mason, Joel D. Boerckel, Ryan K. Roeder, Scott S. Howard
    Abstract:

    Super-resolution fluorescence microscopy is an important tool in biomedical research for its ability to discern features smaller than the diffraction limit. However, due to its difficult implementation and high cost, the super-resolution microscopy is not feasible in many applications. In this paper, we propose and demonstrate a saturation-based super-resolution fluorescence microscopy technique that can be easily implemented and requires neither additional hardware nor complex post-processin…

    Date Published:
    2018-04
  • Author(s):
    Pavel A. Brodkiy, Qinfeng Wu, Francisco J. Huizar, Dharsan K. Soundarrajan, Cody Narciso, Megan evis, Ninfamaria Arredondo-Walsh, Jianxu Chen, Peixian Liang, Danny Z. Chen, Jeremiah James Zartman
    Abstract:

    Organ development is driven by a set of patterned inductive signals. However, how these signals are integrated to coordinate tissue patterning is still poorly understood. Calcium ions (Ca2+) are critical signaling components involved in signal integration and are regulated by a core Ca2+ signaling toolkit. Ca2+ signaling encodes a significant fraction of information in cells through both amplitude and frequency-dependent regulation of transcription factors and key regulatory enzymes. A range …

    Date Published:
    2017-09
  • Author(s):
    Cody E. Narcisco, Nicholas M. Contento, Thomas J. Storey, David J. Hoelzle, Jeremiah J. Zartman
    Abstract:

    Mechanical forces are critical but poorly understood inputs for organogenesis and wound healing. Calcium ions (Ca2+) are critical second messengers in cells for integrating environmental and mechanical cues, but the regulation of Ca2+ signaling is poorly understood in developing epithelial tissues. Here we report a chip-based regulated environment for microorgans that enables systematic investigations of the crosstalk between an organ’s mechanical stress environment and biochemical signaling …

    Date Published:
    2017-07
  • Author(s):
    Qinfeng Wu, Pavel Aleksandrovich Brodkiy, Francisco Javier Huizar, Jamison John Jangula, Cody Narciso, Megan Kathleen Levis, Teresa Brito-Robinson, Jeremiah J. Zartman
    Abstract:

    Recently, organ-scale intercellular Ca2+ transients (ICTs) were reported in the Drosophila wing disc. However, the functional in vivo significance of ICTs remains largely unknown. Here we demonstrate the in vivo relevance of intercellular Ca2+ signaling and its impact on wing development. We report that Ca2+ signaling in vivo decreases as wing discs mature. Ca2+ signaling ex vivo responds to fly extract in a dose-dependent manner. This suggests ICTs occur in vivo due to chemical stimulus that…

    Date Published:
    2017-09
  • Author(s):
    M. McFadden, J. Loconsole, A. J. Schockling, R. Nerenberg, J. P. .Pavassich
    Abstract:

    Peracetic acid (PAA) is an alternative disinfectant that may be effective for combined sewer overflow (CSO) disinfection, but little is known about the effect of particle size on PAA disinfection efficiency. In this work, PAA and hypochlorite were compared as disinfectants, with a focus on the effect of wastewater particles. Inactivation experiments were conducted on suspended cultures of Escherichia coli and wastewater suspended solids. Tested size fractions included particle diameters < …

    Date Published:
    2017-12
  • Author(s):
    Devon E. Mason, James H. Dawahare, Daniel J. Horan, Genevieve D. Vigil, Scott S. Howard,, Alexander G. Robling, , Teresita M. Bellido, Joel D. Boerckel
    Abstract:

    The functions of the paralogous transcriptional coactivators Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ) in bone are controversial. Each has been observed to promote or inhibit osteogenesis in vitro, with reports of both equivalent and divergent functions. Their combinatorial roles in bone physiology are unknown. We report that combinatorial YAP/TAZ deletion from skeletal lineage cells, using Osterix-Cre, caused an osteogenesis imperfecta-like phe…

    Date Published:
    2018-05
  • Author(s):
    Christopher D. Kagelman, Devon E. Mason, James H. Dawahare, Genevieve D. Vigil, Scott S. Howard, Teresita M. Bellido, Alexander G. Robling, Joel Boerckel
    Abstract:

    The functions of the transcriptional co-activators YAP and TAZ in bone are controversial. Each has been observed to either promote or inhibit osteogenesis in vitro, while their roles in bone development are unknown. Here we report that combinatorial YAP/TAZ deletion from skeletal cells in mice caused osteogenesis imperfecta with severity dependent on targeted cell lineage and allele dosage. Osteocyte-conditional deletion impaired bone accrual and matrix collagen, while allele dosage-dependent…

    Date Published:
    2017-05
  • Author(s):
    Jürgen Thanhofer-Pilisch, Alexander Lang, Michael Vierhauser, Rick Rabiser
    Abstract:

    Domain-specific languages (DSLs) are frequently used in software engineering. In contrast to general-purpose languages, DSLs are designed for a special purpose in a particular domain. Due to volatile user requirements and new technologies DSLs, similar to the software systems they describe or produce, are subject to continuous evolution. This work explores existing research on DSL evolution to summarize, structure and analyze this area of research, and to identify trends and open issues. We c…

  • Author(s):
    Michael Vierhauser, Sean Bayley, Jane Wyngaard, Jinghui Cheng, Wandi Xiong, Robyn Lutz, Joshua Huseman, Jane Cleland-Huang
    Abstract:

    The growing adoption of small unmanned aircraft systems (sUAS) for tasks such as eCommerce, aerial surveillance, and environmental monitoring introduces the need for new safety mechanisms in an increasingly cluttered airspace. Safety assurance cases (SAC) provide a state-of-the-art solution for reasoning about system and software safety in numerous safety-critical domains. We propose a novel approach based on the idea of interlocking safety cases. The sUAS infrastructure safety case (iSAC) sp…

  • Author(s):
    Jane Wyngaard, Samuel S.C. Rund, Gregory R. Madey, Michael Vierhauser, Jane Cleland-Huang
    Abstract:

    Remotely Piloted Aircraft Systems (RPAS) are an emerging application area for many industries including surveillance, agriculture monitoring, and vector-borne disease control. With drastically lower costs and increasing performance and autonomy, future application evolution will more than likely include the use of the RPAS swarms. Several largely successful experiments in recent years, using off the shelf small Unmanned Aircraft Systems (sUAS) have been conducted to address the long standing …

  • Author(s):
    Rick Rabiser, Sam Guinea, Michael Vierhauser, Luciano Baresi , Paul Grünbacher
    Abstract:

    The full behavior of complex software systems often only emerges during operation. They thus need to be monitored at run time to check that they adhere to their requirements. Diverse runtime monitoring approaches have been developed in various domains and for different purposes. Their sheer number and heterogeneity, however, make it hard to find the right approach for a specific application or purpose. The aim of our research therefore was to develop a comparison framework for runtime monitor…