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  • Inventor(s):
    John H. Adams, Malcolm J. Fraser, Bharath Balu, Douglas A. Shoue
    Patent Number:
    US 7932088 B2
    Description:

    The present invention provides molecular methods for efficiently transforming the genome of common disease-transmitting parasites, such as Plasmodium falciparum. The transformation efficiencies are improved up to 100 times over those conventionally known. The methods provide high saturation of the target parasite genome, of 50% or greater, and target non-specifically TTAA-rich sites in the parasite genome. The invention also discloses a model that may be used to functionally annotate the geno…

    Date Issued:
    2011-04-26
    Resource Type
    Patent
  • Inventor(s):
    Paul D. Shirk, Malcolm J. Fraser, Teresa A. Elick, Omaththage P. Perera
    Patent Number:
    US 6551825 B2
    Description:

    The present invention is directed to nucleic acid and amino acid sequences for transformation constructs containing piggyBac or tagalong transposable elements. These constructs allow for the precise excision and insertion of heterologous DNA into a host cell.

    Date Issued:
    2003-04-22
    Resource Type
    Patent
  • Inventor(s):
    Paul D. Shirk, Malcolm J. Fraser, Teresa A. Elick, Omaththage P. Perera
    Patent Number:
    US 6218185 B2
    Description:

    The present invention is directed to nucleic acid and amino acid sequences for transformation constructs containing piggyBac or tagalong transposable elements. These constructs allow for the precise excision and insertion of heterologous DNA into a host cell.

    Date Issued:
    2001-04-17
    Resource Type
    Patent
  • Inventor(s):
    Malcolm J. Fraser
    Patent Number:
    US 9707257 B2
    Description:

    Described is a unique class of antiviral molecule that can be applied to control and eliminate HIV infection in patients using myeloablation therapies and replenishment with transformed bone marrow stem cells programmed to express the antiviral molecule. These anti-viral molecules target the HIV genome in a highly conserved domain, and when expressed in cells prior to infection will cause the cell to die upon infection with HIV. Cell death insures no proliferation of new virus. Reconstituting…

    Date Issued:
    2017-07-18
    Resource Type
    Patent
  • Inventor(s):
    Malcolm J. Fraser, Donald L. Jarvis
    Patent Number:
    US 9357755 B2
    Description:

    A transgenic silkworm system for recombinant glycoprotein production is provided.

    Date Issued:
    2016-06-07
    Resource Type
    Patent
  • Inventor(s):
    Malcolm J. Fraser, Xu Li
    Patent Number:
    US 6962810 B2
    Description:

    More efficient transfer of genes into host cells or embryos to transform the cells or embryos is facilitated by transposition vectors using the minimal amount of nucleotide sequences in the transposon piggyBac required for gene transfer. The transformed cells or embryos may be developed into transgenic organisms.

    Date Issued:
    2005-11-08
    Resource Type
    Patent
  • Inventor(s):
    Malcolm J. Fraser, Xu Li
    Patent Number:
    US 7105343 B2
    Description:

    The present invention provides efficient transfer of genes into host cells or embryos to transform the cells or embryos by transposition vectors using the minimal amount of nucleotide sequences in the transposon piggyBac required for gene transfer. The transformed cells or embryos may also be developed into transgenic organisms.

    Date Issued:
    2006-09-12
    Resource Type
    Patent
  • Inventor(s):
    Malcolm J. Fraser, Xu Li
    Patent Number:
    US 10087463 B2
    Description:

    The present invention provides a method for transforming an insect genome that has a much enhanced transformation frequency. The vectors and plasmids employed in the method are further described as transposition vectors that include a minimal amount of nucleotide sequence homologous to a 5’ region and a 3’ region of a native piggyBac nucleic acid sequence. The transformed cells or embryos may also be developed into transgenic organisms. Disclosed are minimal piggyBac-based plasmid con…

    Date Issued:
    2018-10-02
    Resource Type
    Patent