Biological Sciences

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  • Inventor(s):
    Malcolm J. Fraser
    Patent Number:
    US 9707257 B2
    Description:

    Described is a unique class of antiviral molecule that can be applied to control and eliminate HIV infection in patients using myeloablation therapies and replenishment with transformed bone marrow stem cells programmed to express the antiviral molecule. These anti-viral molecules target the HIV genome in a highly conserved domain, and when expressed in cells prior to infection will cause the cell to die upon infection with HIV. Cell death insures no proliferation of new virus. Reconstituting…

    Date Issued:
    2017-07-18
    Record Visibility:
    Public
    Resource Type
    Patent
  • Inventor(s):
    Malcolm J. Fraser, Donald L. Jarvis
    Patent Number:
    US 9357755 B2
    Description:

    A transgenic silkworm system for recombinant glycoprotein production is provided.

    Date Issued:
    2016-06-07
    Record Visibility:
    Public
    Resource Type
    Patent
  • Inventor(s):
    Xu Li, Malcolm J. Fraser
    Patent Number:
    US 10087463 B2
    Description:

    The present invention provides a method for transforming an insect genome that has a much enhanced transformation frequency. The vectors and plasmids employed in the method are further described as transposition vectors that include a minimal amount of nucleotide sequence homologous to a 5’ region and a 3’ region of a native piggyBac nucleic acid sequence. The transformed cells or embryos may also be developed into transgenic organisms. Disclosed are minimal piggyBac-based plasmid con…

    Date Issued:
    2018-10-02
    Record Visibility:
    Public
    Resource Type
    Patent