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  • Author(s):
    Yumiko Tokusumi, Tsuyoshi Tokusumi, Robert A. Schulz
    Abstract:

    Acute inflammation can cause serious tissue damage and disease in physiologically-challenged organisms. The precise mechanisms leading to these detrimental effects remain to be determined. In this study, we utilize a reproducible means to induce cellular immune activity in Drosophila larvae in response to mechanical stress. That is, forceps squeeze-administered stress induces lamellocytes, a defensive hemocyte type that normally appears in response to wasp infestation of larvae. The posterior…

    Date Published:
    2018-07
    Record Visibility:
    Public
  • Author(s):
    Tsuyoshi Tokusumi, Yumiko Tokusumi, Robert A. Schulz
    Abstract:

    Hedgehog (Hh) pathway signaling is crucial for the maintenance of blood cell progenitors in thelymph gland hematopoietic organ present in Drosophila third instar larvae. Previous studies fromour lab have likewise shown the importance of the mir-7 and bag of marbles (bam) genes in main-taining the progenitor state. Thus, we sought to investigate a possible interaction between the Hhpathway and mir-7/bam in the prohemocyte population within this hematopoietic tissue. Gain offunction mir-7 was a…

    Date Published:
    2018-04
    Record Visibility:
    Public