Biological Sciences

Search CurateND

Search criteria:

Department or Unit: Biological Sciences remove × Type of Work: Article remove ×
Clear all

List of files deposited in CurateND that match your search criteria

  • Author(s):
    Jeff Schorey, Yong Cheng
    Abstract:

    Extracellular vesicles (EVs) have been shown to carry microbial components and function in the host defense against infections. In this study, we demonstrate that Mycobacterium tuberculosis (M.tb) RNA is delivered into macrophage-derived EVs through an M.tb SecA2-dependent pathway, and that EVs released from M.tb-infected macrophages stimulate a host RIG-I/MAVS/TBK1/IRF3 RNA sensing pathway, leading to type I interferon production in recipient cells. These EVs also promote, in a RIG-I/MAVS-de…

    Date Published:
    2018-06
  • Author(s):
    Li Li, Yong Cheng, Scott Emrich, Jeffrey Schorey
    Abstract:

    Endothelial cells play an essential role in regulating an immune response through promoting leukocyte adhesion and cell migration and production of cytokines such as TNFα. Regulation of endothelial cell immune function is tightly regulated and recent studies suggest that extracellular vesicles (EVs) are prominently involved in this process. However, the importance of EVs in regulating endothelial activation in the context of a bacterial infection is poorly understood. To begin addressing this…

    Date Published:
    2018-05
  • Author(s):
    Li Li, Yong Cheng
    Abstract:

    Endothelial cells play an essential role in regulating an immune response through promoting leukocyte adhesion and cell migration and production of cytokines such as TNFα. Regulation of endothelial cell immune function is tightly regulated and recent studies suggest that extracellular vesicles (EVs) are prominently involved in this process. However, the importance of EVs in regulating endothelial activation in the context of a bacterial infection is poorly understood. To begin addressing this…

    Date Published:
    2018-05