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  • Inventor(s):
    Kent Walters, John G. Duman, Anthony S. Serianni
    Patent Number:
    US 8604002 B1
    Description:

    The invention provides an antifreeze glycolipid compounds and composition comprising a polysaccharide moiety of Formula I: missing image wherein D-Manp represents a D-mannopyranose moiety, D-Xylp represents a D-xylopyranose moiety, and n is about 5 to about 70; and one or more lipid moieties covalently linked to the polysaccharide moiety of Formula I or electrostatically associated with the polysaccharide moiety of Formula I. The antifreeze glycolipid compounds and compositions can be u…

    Date Issued:
    2013-12-10
    Resource Type
    Patent
  • Inventor(s):
    Mark A. Suckow, William R. Wolter
    Patent Number:
    US 8802113 B2
    Description:

    Compositions suitable for use as adjuvants in the preparation of vaccines, particularly those vaccines useful in the treatment of cancer, are provided. Methods for inhibiting tumor growth in an animal are also disclosed. Methods for immunizing an animal against cancer, such as prostate cancer, are also described. The adjuvants described are comprised of an extracellular matrix material, such as small intestinal submucosal (SIS) tissue. The preparations may take the form of sheets, gels, liqui…

    Date Issued:
    2014-08-12
    Resource Type
    Patent
  • Inventor(s):
    Mark A. Suckow, Michael C. Hiles
    Patent Number:
    US 8,778,362 B2
    Description:

    Disclosed are mammalian tumor and/or cancer cell conditioned substrate preparations having tumor inhibiting activity. In some embodiments, the mammalian tumor and/or cancer cell conditioned substrate preparations are essentially free of cellular components. These preparations comprise a conditioned heterologous acellular collagenous tissue preparation, and may be prepared using a mammalian extracellular matrix substrate. The conditioned substrates include many different anti-tumor and/or anti…

    Date Issued:
    2014-07-15
    Resource Type
    Patent
  • Inventor(s):
    Mark A. Suckow, William R. Wolter
    Patent Number:
    US 8846059 B2
    Description:

    Compositions suitable for use as ovarian cancer and/or tumor adjuvants in the preparation of ovarian cancer vaccines, particularly those vaccines useful in the treatment of human ovarian cancer, are provided. The ovarian cancer adjuvants described are comprised of an extracellular matrix material, such as small intestinal submucosal (SIS) tissue. The preparations may take the form of sheets, gels, liquids (injectable), tracer, or other solid or semi-solid preparation. Also disclosed are ovari…

    Date Issued:
    2014-09-30
    Resource Type
    Patent
  • Inventor(s):
    Mark A. Suckow, William R. Wolter, Paul J. Hall
    Patent Number:
    US 9220770 B2
    Description:

    Disclosed are vaccines and vaccine adjuvants useful in the treatment and/or prevention of infection and diseases associated with infectious pathogens, such as tetanus, as well as diseases associated with biological toxins. Also provided are methods of preparing an adjuvant and the vaccine containing the adjuvant. Methods are also provided for vaccinating/immunizing an animal against infection and diseases associated with infectious pathogens, such as tetanus, and other diseases associated wit…

    Date Issued:
    2015-12-29
    Resource Type
    Patent
  • Inventor(s):
    Crislyn D'Souza-Schorey, James W. Clancy, Vandhana Muralidharan-Chari
    Patent Number:
    US 9329188 B2
    Description:

    The present application relates to the isolation and analysis of populations of microvesicles and the identification of invasive microvesicles in the populations such as populations of microvesicles that are shed by tumor cells. Invasive microvesicles from tumor cells contain a variety of specific proteins, such as ARF6.

    Date Issued:
    2016-05-03
    Resource Type
    Patent
  • Inventor(s):
    Jeffrey S. Schorey, Karen M. Dobos
    Patent Number:
    US 9255924 B2
    Description:

    The invention provides methods for the detection of M. tuberculosis proteins in or on exosomes derived from infected individuals. The methods can use a proteomic approach including mass spectroscopy, data mining and multiplex reaction monitoring to quickly examine a large amount of M. tuberculosis proteins to determine the best biomarkers for use in diagnostic tests to identify active TB patients.

    Date Issued:
    2016-02-09
    Resource Type
    Patent
  • Inventor(s):
    Mark A. Suckow, William R. Wolter
    Patent Number:
    US 8,778,360 B2
    Description:

    Compositions suitable for use as adjuvants in the preparation of vaccines, particularly those vaccines useful in the treatment of cancer, are provided. Methods for inhibiting tumor growth in an animal are also disclosed. Methods for immunizing an animal against cancer, such as prostate cancer, are also described. The adjuvants described are comprised of an extracellular matrix material, such as small intestinal submucosal (SIS) tissue. The preparations may take the form of sheets, gels, liqui…

    Date Issued:
    2014-07-15
    Resource Type
    Patent
  • Inventor(s):
    Mark A. Suckow, William R. Wolter, Valerie Sailes
    Patent Number:
    US 9283266 B2
    Description:

    Disclosed are compositions and pharmaceutical preparations suitable for inhibiting metastasis of a malignant cancer in an animal. Methods for inhibiting and/or eliminating metastasis in an animal are also provided. In some embodiments, the preparations and compositions comprise a whole cell tumor preparation comprising tumor tissue cells and tumor connective tissue stroma. The disclosure also provides methods for preparing the preparations and pharmaceutical preparations. Inhibition of metast…

    Date Issued:
    2016-03-15
    Resource Type
    Patent
  • Inventor(s):
    Malcolm J. Fraser
    Patent Number:
    US 9707257 B2
    Description:

    Described is a unique class of antiviral molecule that can be applied to control and eliminate HIV infection in patients using myeloablation therapies and replenishment with transformed bone marrow stem cells programmed to express the antiviral molecule. These anti-viral molecules target the HIV genome in a highly conserved domain, and when expressed in cells prior to infection will cause the cell to die upon infection with HIV. Cell death insures no proliferation of new virus. Reconstituting…

    Date Issued:
    2017-07-18
    Resource Type
    Patent
  • Inventor(s):
    Mark A. Suckow, William R. Wolter, Paul J. Hall
    Patent Number:
    US 9308252 B2
    Description:

    Disclosed are vaccines and vaccine adjuvants useful in the treatment and/or prevention of infection and diseases associated with infectious pathogens, such as tetanus, as well as diseases associated with biological toxins. Also provided are methods of preparing an adjuvant and the vaccine containing the adjuvant. Methods are also provided for vaccinating/immunizing an animal against infection and diseases associated with infectious pathogens, such as tetanus, and other diseases associated wit…

    Date Issued:
    2016-04-12
    Resource Type
    Patent
  • Inventor(s):
    Malcolm J. Fraser, Donald L. Jarvis
    Patent Number:
    US 9357755 B2
    Description:

    A transgenic silkworm system for recombinant glycoprotein production is provided.

    Date Issued:
    2016-06-07
    Resource Type
    Patent