Biological Sciences

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  • Inventor(s):
    John H. Adams, Malcolm J. Fraser, Bharath Balu, Douglas A. Shoue
    Patent Number:
    US 7932088 B2
    Description:

    The present invention provides molecular methods for efficiently transforming the genome of common disease-transmitting parasites, such as Plasmodium falciparum. The transformation efficiencies are improved up to 100 times over those conventionally known. The methods provide high saturation of the target parasite genome, of 50% or greater, and target non-specifically TTAA-rich sites in the parasite genome. The invention also discloses a model that may be used to functionally annotate the geno…

    Date Issued:
    2011-04-26
    Resource Type
    Patent
  • Inventor(s):
    Paul D. Shirk, Malcolm J. Fraser, Teresa A. Elick, Omaththage P. Perera
    Patent Number:
    US 6551825 B2
    Description:

    The present invention is directed to nucleic acid and amino acid sequences for transformation constructs containing piggyBac or tagalong transposable elements. These constructs allow for the precise excision and insertion of heterologous DNA into a host cell.

    Date Issued:
    2003-04-22
    Resource Type
    Patent
  • Inventor(s):
    John G. Duman
    Patent Number:
    US 5633451 B2
    Description:

    The present invention is directed to transgenic plants having nucleic acid sequences encoding Dendroides canadensis thermal hysteresis proteins. The THPs of Dendroides have significantly greater thermal hysteresis activity than any other known anti-freeze protein. The thermal hysteresis activity of the purified THPs can be further enhanced by combining the THPs with various “activating” compounds.

    Date Issued:
    1997-05-27
    Resource Type
    Patent
  • Inventor(s):
    Paul D. Shirk, Malcolm J. Fraser, Teresa A. Elick, Omaththage P. Perera
    Patent Number:
    US 6218185 B2
    Description:

    The present invention is directed to nucleic acid and amino acid sequences for transformation constructs containing piggyBac or tagalong transposable elements. These constructs allow for the precise excision and insertion of heterologous DNA into a host cell.

    Date Issued:
    2001-04-17
    Resource Type
    Patent
  • Inventor(s):
    John G. Duman
    Patent Number:
    US 5627051 B2
    Description:

    The present invention is directed to nucleic acid sequences encoding Dendroides canadensis thermal hysteresis proteins. The THPs of Dendroides have significantly greater thermal hysteresis activity than any other known anti-freeze protein. The thermal hysteresis activity of the purified THPs can be further enhanced by combining the THPs with various “activating” compounds.

    Date Issued:
    1997-05-06
    Resource Type
    Patent
  • Inventor(s):
    Philip C. Trexler
    Patent Number:
    US 3016284 B2
    Description:

    This invention relates to a sterile container for introducing material into apparatus having a controlled atmosphere. The invention finds particular utility for use in connection with apparatus of the character disclosed in my copending patent application for Isolator Structure, Serial No. 656,396, filed .May 1, 1957.

    Date Issued:
    1962-01-09
    Resource Type
    Patent
  • Inventor(s):
    Crislyn D'Souza-Schorey, James W. Clancy, Vandhana Muralidharan-Chari
    Patent Number:
    US 8420334 B2
    Description:

    The present application relates to the isolation and analysis of populations of microvesicles, such as populations of microvesicles that are shed by tumor cells and contain the protein ARF6. Invasive microvesicles from tumor cells contain a variety of specific proteins, including ARF6.

    Date Issued:
    2013-04-16
    Resource Type
    Patent
  • Inventor(s):
    Philip C. Trexler
    Patent Number:
    US 3059831 B2
    Description:

    This invention relates to improvements in connections between two sealed chambers, and methods of making the same, and more particularly to connections between an isolator for containing biological and other specimens within a controlled environment and a container therein and containing material to be introduced into the isolator or adapted to receive material to be discharged from an isolator.

    Date Issued:
    1962-10-23
    Resource Type
    Patent
  • Inventor(s):
    Philip C. Trexler
    Patent Number:
    US 3051163 B2
    Description:

    This invention relates to improvements in isolating devices, and more particularly to a device providing an enclosure for use to confine contamination while experiments and tests involving contamination of test specimens are being made, or to exclude contamination from a space within which tests and experiments are conducted. Contamination, as herein mentioned, may be biological or radiological or chemical.

    Date Issued:
    1962-08-28
    Resource Type
    Patent
  • Inventor(s):
    Philip C. Trexler
    Patent Number:
    US 2786464 B2
    Description:

    This invention relates to improvements in biological apparatus, and more particularly to apparatus of the character illustrated in my Patent No. 2,705,489, dated April 5, 1955.

    Date Issued:
    1957-03-26
    Resource Type
    Patent
  • Inventor(s):
    Mark A. Suckow, William R. Wolter, Morris Pollard
    Patent Number:
    US 8257715 B2
    Description:

    Compositions comprising a tissue vaccine that include a mixture of heterogeneous tissue obtained from tumors and connective tissues. Vaccines comprising these compositions are also provided, as well as methods of using the vaccines in the treatment and/or inhibition of tumor growth, and particularly prostate tumor growth and cancers. The preparations may be defined as vaccines comprising tumor cells and connective (stromal) tissues derived from xenogeneic animals. Preparations comprising the …

    Date Issued:
    2012-09-04
    Resource Type
    Patent
  • Inventor(s):
    Philip C. Trexler
    Patent Number:
    US 2705489 B2
    Description:

    This invention relates to improvements in biological apparatus. More particularly, it relates to apparatus for maintaining and working with biological specimens in a controlled environment, or to con?ne and control a contaminated environment, whether biological, chemical or radio-active.

    Date Issued:
    1955-04-05
    Resource Type
    Patent