Search CurateND

Search criteria:

Department or Unit: Chemistry and Biochemistry remove × Department or Unit: University of Notre Dame remove ×
Clear all

List of files deposited in CurateND that match your search criteria

  • Inventor(s):
    Kent Walters, John G. Duman, Anthony S. Serianni
    Patent Number:
    US 8604002 B1
    Description:

    The invention provides an antifreeze glycolipid compounds and composition comprising a polysaccharide moiety of Formula I: missing image wherein D-Manp represents a D-mannopyranose moiety, D-Xylp represents a D-xylopyranose moiety, and n is about 5 to about 70; and one or more lipid moieties covalently linked to the polysaccharide moiety of Formula I or electrostatically associated with the polysaccharide moiety of Formula I. The antifreeze glycolipid compounds and compositions can be u…

    Date Issued:
    2013-12-10
    Record Visibility:
    Public
    Resource Type
    Patent
  • Inventor(s):
    Shahriar Mobashery, Dusan Hesek, Mayland Chang
    Patent Number:
    US 8859620 B2
    Description:

    The invention provides antimicrobial compounds and compositions, and methods of using them. The compounds and compositions include, for example, a compound of any one of Formulas I-X. The invention further provides methods of preparing the compounds, and useful intermediates for their preparation. The compounds can possess highly specific and selective activity, such as antibacterial activity and/or enzymatic inhibitory activity. Accordingly, the compounds and compositions can be used to trea…

    Date Issued:
    2014-10-14
    Record Visibility:
    Public
    Resource Type
    Patent
  • Inventor(s):
    Olaf G. Wiest, Frederick R. Maxfield, Paul Helquist
    Patent Number:
    US 9333222 B2
    Description:

    Embodiments herein relate to the field of lysosomal storage disorders, and, more specifically, to methods of treating lysosomal storage disorders such as Niemann-Pick type C disease, for instance with inhibitors of histone deacetylases, particularly inhibitors of class 1 histone deacetylases. In various embodiments, methods of treating Niemann-Pick type C disease with inhibitors of class 1 histone deacetylases are described.

    Date Issued:
    2016-05-10
    Record Visibility:
    Public
    Resource Type
    Patent
  • Inventor(s):
    Marvin J. Miller, Cheng Ji, Patricia A. Miller
    Patent Number:
    US 9302012 B2
    Description:

    An artificial tris-catecolate siderophore with a tripodal backbone and its conjugates with ampicillin and amoxicillin were synthesized. Both conjugates exhibited significantly enhanced in vitro antibacterial activities against Gram-negative species compared to the parent drugs, especially against P. aeruginosa. The conjugates appear to be assimilated by an induced bacterial iron transport process as their activities were inversely related to iron concentration. The easily synthesized tris-cat…

    Date Issued:
    2016-04-05
    Record Visibility:
    Public
    Resource Type
    Patent
  • Inventor(s):
    Steven Buechler, Amanda B. Hummon
    Patent Number:
    US 9580756 B2
    Description:

    Compositions/methods for employing fresh-frozen or FFPE colon cancer tissue in left side colon cancer (LCC) and right-side colon cancer (RCC) disease patients for risk of relapse assessment/stratification is provided (3 strata and a 4 strata methodology). An RCC gene panel of 4 genes (FAM69A, CDX2, FAM84A, ITGA3), and 9 genes (FAM69A, CDX2, ITGA3, FAM84A, ITPRIP, RAB3B, SMAD3, PCSK5, MMP28), is provided. An LCC gene panel of 4 genes (NOX4, WNT5A, MMP3, IBSP), and a 9 genes (MMP3, WINT5A, NOX4…

    Date Issued:
    2017-02-28
    Record Visibility:
    Public
    Resource Type
    Patent
  • Inventor(s):
    Toni Lee Owen Barstis, Patrick J. Flynn, Marya Lieberman
    Patent Number:
    US 9354181 B2
    Description:

    An analytical device, in particular, a paper analytical device (PAD), for detection of at least two chemical components indicative of a low quality pharmaceutical product is provided. The analytical device can include a porous, hydrophilic medium, at least two assay regions associated with the porous, hydrophilic medium, at least one assay reagent or precursor thereof in the assay regions, and at least one optically readable information zone.

    Date Issued:
    2016-05-31
    Record Visibility:
    Public
    Resource Type
    Patent
  • Inventor(s):
    Bradley D. Smith
    Patent Number:
    US 9353092 B2
    Description:

    The present disclosure provides compositions and methods for the synthesis and use of croconaine compounds. The disclosed compounds are easily prepared from croconic acid. A halothiophene is reacted with an alkanolamine, the resulting aminothiophene is modified by appending a desired functional group to the hydroxyl group, and the modified aminothiophene is reacted with croconic acid to form the final compound. Applications of such croconaine compounds include photothermal imaging, phototherm…

    Date Issued:
    2016-05-31
    Record Visibility:
    Public
    Resource Type
    Patent
  • Inventor(s):
    Norman Dovichi, Liangliang Sun, Guijie Zhu
    Patent Number:
    US 9465014 B2
    Description:

    The invention provides a sheath-flow interface for producing electrospray from a capillary. The electrospray generated by the interface can be used as the source of ions for mass spectrometry. Electrokinetic flow in the interface can move a sheath liquid past the end of a capillary so as to mix with an analyte effluent discharged from the capillary. The sheath liquid and analyte mixture can be directed to an electrospray emitter to generate an electrospray.

    Date Issued:
    2016-10-11
    Record Visibility:
    Public
    Resource Type
    Patent
  • Inventor(s):
    Norman Dovichi, Liangliang Sun, Guijie Zhu
    Patent Number:
    US 9362102 B2
    Description:

    The invention provides a sheath-flow interface for producing electrospray from a capillary. The electrospray generated by the interface can be used as the source of ions for mass spectrometry. Electrokinetic flow in the interface can move a sheath liquid past the end of a capillary so as to mix with an analyte effluent discharged from the capillary. The sheath liquid and analyte mixture can be directed to an electrospray emitter to generate an electrospray.

    Date Issued:
    2016-06-07
    Record Visibility:
    Public
    Resource Type
    Patent
  • Inventor(s):
    Garrett C. Moraski, Marvin J. Miller
    Patent Number:
    US 9605002 B2
    Description:

    The invention provides a series of 5,5-heteroaromatic compounds, syntheses thereof, compositions thereof, and methods of using such compounds and compositions. Various embodiments provide methods of killing and/or inhibiting the growth of M. tuberculosis and/or M. avium, and methods of treating, preventing, and/or ameliorating M. tuberculosis and/or M. avium infections in a subject. In various embodiments, the 5,5-heteroaromatic compound is N-(4-(4-chlorophenoxy)benzyl)-2,6-dimethylimidazo[2,…

    Date Issued:
    2017-03-28
    Record Visibility:
    Public
    Resource Type
    Patent
  • Inventor(s):
    Mayland Chang, Shahriar Mobashery
    Patent Number:
    US 9604957 B2
    Description:

    The invention provides compounds, compositions, and methods for the treatment of diseases, disorders, or conditions that are modulated by matrix metalloproteinases (MMPs). The compounds can be selective MMP inhibitors, for example, selective inhibitors of MMP-2, MMP-9, and/or MMP-14. The disease, disorder, or condition can include, for example, stroke, neurological disorders, ophthalmological disorders, or wounds, such as chronic wounds or diabetic wounds.

    Date Issued:
    2017-03-28
    Record Visibility:
    Public
    Resource Type
    Patent
  • Inventor(s):
    Marvin J. Miller, Rohit Tiwari
    Patent Number:
    US 9481683 B2
    Description:

    A compound, having the following formula: ##STR00001## or resonance form thereof, or salt thereof, or salt of resonance form thereof is provided, wherein R.sup.1-R.sup.4 and n are defined herein. Compositions and methods including the compound are also provided.

    Date Issued:
    2016-11-01
    Record Visibility:
    Public
    Resource Type
    Patent