Chemistry and Biochemistry

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  • Inventor(s):
    Steven Buechler, Amanda B. Hummon
    Patent Number:
    US 9580756 B2
    Description:

    Compositions/methods for employing fresh-frozen or FFPE colon cancer tissue in left side colon cancer (LCC) and right-side colon cancer (RCC) disease patients for risk of relapse assessment/stratification is provided (3 strata and a 4 strata methodology). An RCC gene panel of 4 genes (FAM69A, CDX2, FAM84A, ITGA3), and 9 genes (FAM69A, CDX2, ITGA3, FAM84A, ITPRIP, RAB3B, SMAD3, PCSK5, MMP28), is provided. An LCC gene panel of 4 genes (NOX4, WNT5A, MMP3, IBSP), and a 9 genes (MMP3, WINT5A, NOX4…

    Date Issued:
    2017-02-28
    Resource Type
    Patent
  • Inventor(s):
    Steven Buechler, Amanda B. Hummon
    Patent Number:
    US 9464328 B2
    Description:

    Genetic biomarkers for left side colon cancer (LCC) (such as expression levels of an RNA transcript or expression product of NOX4, MMP3, or a combination) and right side colon cancer (RCC) (such as expression levels of an RNA transcript or expression product of CDCX2, FAM69A, or a combination), are disclosed. Methods for using the biomarkers in providing a prognosis of relapse-free survival probability in patients having LCC or RCC are also presented. Prognostic panels using gene expression v…

    Date Issued:
    2016-10-11
    Resource Type
    Patent
  • Inventor(s):
    Steven Buechler, Amanda B. Hummon
    Patent Number:
    US 10,087,489 B2
    Description:

    Genetic biomarkers for left side colon cancer (LCC) (such as expression levels of an RNA transcript or expression product of NOX4, MMP3, or a combination) and right side colon cancer (RCC) (such as expression levels of an RNA transcript or expression product of CDCX2, FAM69A, or a combination), are disclosed. Methods for using the biomarkers in providing a prognosis of relapse-free survival probability in patients having LCC or RCC are also presented. Prognostic panels using gene expression v…

    Date Issued:
    2018-10-02
    Resource Type
    Patent