Chemistry and Biochemistry

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  • Inventor(s):
    James McGivney, Guijie Zhu, Norman Dovichi
    Patent Number:
    US 9159537 B2
    Description:

    Described herein is a method and system for on-line coupling of capillary isoelectric focusing (cIEF) to high-resolution mass spectrometry in which a sheath flow buffer comprising polar organic solvent and organic acid is used as both an immobilization solution for (cIEF) and an ionization solution for electrospray ionization (ESI).

    Date Issued:
    2015-10-13
    Record Visibility:
    Public
    Resource Type
    Patent
  • Inventor(s):
    Norman Dovichi, Liangliang Sun, Guijie Zhu
    Patent Number:
    US 9362102 B2
    Description:

    The invention provides a sheath-flow interface for producing electrospray from a capillary. The electrospray generated by the interface can be used as the source of ions for mass spectrometry. Electrokinetic flow in the interface can move a sheath liquid past the end of a capillary so as to mix with an analyte effluent discharged from the capillary. The sheath liquid and analyte mixture can be directed to an electrospray emitter to generate an electrospray.

    Date Issued:
    2016-06-07
    Record Visibility:
    Public
    Resource Type
    Patent
  • Inventor(s):
    Norman Dovichi, Liangliang Sun, Guijie Zhu
    Patent Number:
    US 9465014 B2
    Description:

    The invention provides a sheath-flow interface for producing electrospray from a capillary. The electrospray generated by the interface can be used as the source of ions for mass spectrometry. Electrokinetic flow in the interface can move a sheath liquid past the end of a capillary so as to mix with an analyte effluent discharged from the capillary. The sheath liquid and analyte mixture can be directed to an electrospray emitter to generate an electrospray.

    Date Issued:
    2016-10-11
    Record Visibility:
    Public
    Resource Type
    Patent