Chemistry and Biochemistry

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  • Inventor(s):
    Marvin J. Miller, Garrett C. Moraski, Jonathan Stefely
    Patent Number:
    US 8729270 B2
    Description:

    Embodiments relate to the field of chemistry and biochemistry, and, more specifically, to anti-cancer compounds, synthesis thereof, and methods of using same. Disclosed herein are various heterocyclic compounds and methods of using the novel anti-cancer compounds to inhibit the growth of a cancer cell, for instance a leukemia, non-small cell lung, central nervous system (CNS), skin, ovarian, renal, prostate, breast, or colon cancer cell. Other embodiments include methods of treating cancer in…

    Date Issued:
    2014-05-20
    Resource Type
    Patent
  • Inventor(s):
    Marvin J. Miller, Cheng Ji, Patricia A. Miller
    Patent Number:
    US 9302012 B2
    Description:

    An artificial tris-catecolate siderophore with a tripodal backbone and its conjugates with ampicillin and amoxicillin were synthesized. Both conjugates exhibited significantly enhanced in vitro antibacterial activities against Gram-negative species compared to the parent drugs, especially against P. aeruginosa. The conjugates appear to be assimilated by an induced bacterial iron transport process as their activities were inversely related to iron concentration. The easily synthesized tris-cat…

    Date Issued:
    2016-04-05
    Resource Type
    Patent
  • Inventor(s):
    Marvin J. Miller, Garrett C. Moraski, Lowell D. Markley, George E. Davis
    Patent Number:
    US 9309238 B2
    Description:

    Embodiments relate to the field of chemistry and biochemistry, and, more specifically, to imidazopyridine compounds, synthesis thereof, and methods of using same. Disclosed herein are various imidazo[1,2-a]pyhdine compounds and methods of using the novel compounds to treat or prevent tuberculosis in a subject or to inhibit fungal growth on plant species. Other embodiments include methods of synthesizing imidazo[1,2-a]pyridine compounds, such as the disclosed imidazo[1,2-a]pyridine compounds.

    Date Issued:
    2016-04-12
    Resource Type
    Patent
  • Inventor(s):
    Marvin J. Miller, Rohit Tiwari
    Patent Number:
    US 9708339 B2
    Description:

    A compound, having the following formula: ##STR00001## or resonance form thereof, or salt thereof, or salt of resonance form thereof is provided, wherein E includes an electrophilic site, and wherein R.sup.1-R.sup.4 and n are defined herein. Compositions and methods including the compound are also provided.

    Date Issued:
    2017-07-18
    Resource Type
    Patent
  • Inventor(s):
    Garrett C. Moraski, Marvin J. Miller
    Patent Number:
    US 9605002 B2
    Description:

    The invention provides a series of 5,5-heteroaromatic compounds, syntheses thereof, compositions thereof, and methods of using such compounds and compositions. Various embodiments provide methods of killing and/or inhibiting the growth of M. tuberculosis and/or M. avium, and methods of treating, preventing, and/or ameliorating M. tuberculosis and/or M. avium infections in a subject. In various embodiments, the 5,5-heteroaromatic compound is N-(4-(4-chlorophenoxy)benzyl)-2,6-dimethylimidazo[2,…

    Date Issued:
    2017-03-28
    Resource Type
    Patent
  • Inventor(s):
    Marvin J. Miller, Rohit Tiwari
    Patent Number:
    US 9481683 B2
    Description:

    A compound, having the following formula: ##STR00001## or resonance form thereof, or salt thereof, or salt of resonance form thereof is provided, wherein R.sup.1-R.sup.4 and n are defined herein. Compositions and methods including the compound are also provided.

    Date Issued:
    2016-11-01
    Resource Type
    Patent
  • Inventor(s):
    Marvin J. Miller, Garrett C. Moraski
    Patent Number:
    US 9617249 B2
    Description:

    Embodiments herein provide compounds and methods of making and using such compounds for prevention and treatment of multidrug resistant bacteria. In particular, embodiments are directed to anti-bacterial agents from benzo[d]heterocyclic scaffolds for prevention and treatment of multidrug resistant bacteria.

    Date Issued:
    2017-04-11
    Resource Type
    Patent
  • Inventor(s):
    Marvin J. Miller, Garrett C. Moraski, Lowell D. Markley, George E. Davis
    Patent Number:
    US 9908876 B2
    Description:

    Embodiments relate to the field of chemistry and biochemistry, and, more specifically, to imidazopyridine compounds, synthesis thereof, and methods of using same. Disclosed herein are various imidazo[1,2-a]pyhdine compounds and methods of using the novel compounds to treat or prevent tuberculosis in a subject or to inhibit fungal growth on plant species. Other embodiments include methods of synthesizing imidazo[1,2-a]pyridine compounds, such as the disclosed imidazo[1,2-a]pyridine compounds.

    Date Issued:
    2018-03-06
    Resource Type
    Patent