Chemistry and Biochemistry

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  • Inventor(s):
    Mayland Chang, Shahriar Mobashery, Renee Bouley
    Patent Number:
    US 9,776,975 B2

    A new class of antibiotics effective against methicillin-resistant Staphylococcus aureus (MRSA) is disclosed. Compounds of this class can impair cell-wall biosynthesis by binding to both the allosteric and the catalytic domains of penicillin-binding protein (PBP) 2a. This class of antibiotics holds promise in reversing obsolescence of staphylococcal PBPs as important targets for antibiotics. Embodiments of the invention thus provide novel antibacterial compounds that target penicillin-binding…

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