Chemistry and Biochemistry

Search CurateND

Filter by:

Search criteria:

Department or Unit: Chemistry and Biochemistry remove × Creator: Mayland Chang remove × Creator: Renee Bouley remove × Type of Work: Master's Thesis OR Patent OR Report remove ×
Clear all

List of files deposited in CurateND that match your search criteria

  • 1

    Patent

    Quinazolinone antibiotics
    Thumbnail
    Inventor(s):
    Mayland Chang, Shahriar Mobashery, Renee Bouley
    Patent Number:
    US 9,776,975 B2
    Description:

    A new class of antibiotics effective against methicillin-resistant Staphylococcus aureus (MRSA) is disclosed. Compounds of this class can impair cell-wall biosynthesis by binding to both the allosteric and the catalytic domains of penicillin-binding protein (PBP) 2a. This class of antibiotics holds promise in reversing obsolescence of staphylococcal PBPs as important targets for antibiotics. Embodiments of the invention thus provide novel antibacterial compounds that target penicillin-binding…

    Date Issued:
    2017-10-03
    Record Visibility:
    Public
    Title
    Quinazolinone antibiotics
    Description
    A new class of antibiotics effective against methicillin-resistant Staphylococcus aureus (MRSA) is disclosed. Compounds of this class can impair cell-wall biosynthesis by binding to both the allosteric and the catalytic domains of penicillin-binding protein (PBP) 2a. This class of antibiotics holds promise in reversing obsolescence of staphylococcal PBPs as important targets for antibiotics. Embodiments of the invention thus provide novel antibacterial compounds that target penicillin-binding proteins and/or other important cellular targets. Methods for inhibiting the growth and/or replication of bacteria using the compounds described herein are also provided. Various embodiments exhibit activity against gram positive bacteria, including drug-resistant strains of Staphylococcus aureus.
    Creator
    Mayland Chang, Shahriar Mobashery, Renee Bouley
    Publisher
    U.S. Patent and Trademark Office
    Language
    English
    Rights
    All rights reserved
    Resource Type
    Patent
1 entry found